2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Ipratropium-d3 bromide

Ipratropium-d3 bromide  (Synonyms: Sch 1000-d3)

Cat. No.: HY-B0241S Purity: ≥98.0%
COA Handling Instructions

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Ipratropium-d3 (bromide) is the deuterium labeled Ipratropium bromide. Ipratropium bromide (Sch 1000) is a muscarinic receptor antagonist, with binding IC50 values of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma[1][2][3].

For research use only. We do not sell to patients.

Ipratropium-d<sub>3</sub> bromide Chemical Structure

Ipratropium-d3 bromide Chemical Structure

Size Price Stock Quantity
1 mg USD 450 In-stock
5 mg USD 1450 In-stock
10 mg USD 2400 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Ipratropium-d3 bromide:

Ipratropium-d3 bromide Related Antibodies

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Description

Ipratropium-d3 (bromide) is the deuterium labeled Ipratropium bromide. Ipratropium bromide (Sch 1000) is a muscarinic receptor antagonist, with binding IC50 values of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ipratropium-d3 bromide Related Antibodies
Molecular Weight

415.38

Formula

C20H27D3BrNO3
Unlabeled CAS

22254-24-6
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC([N+]1([C@H]2CC[C@H]1CC(OC(C(CO)C3=CC=CC=C3)=O)C2)C([2H])([2H])[2H])C.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (240.74 mM; Need ultrasonic)

H2O : 100 mg/mL (240.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4074 mL 12.0372 mL 24.0743 mL
5 mM 0.4815 mL 2.4074 mL 4.8149 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O 1 mM 2.4074 mL 12.0372 mL 24.0743 mL 60.1859 mL
5 mM 0.4815 mL 2.4074 mL 4.8149 mL 12.0372 mL
10 mM 0.2407 mL 1.2037 mL 2.4074 mL 6.0186 mL
15 mM 0.1605 mL 0.8025 mL 1.6050 mL 4.0124 mL
20 mM 0.1204 mL 0.6019 mL 1.2037 mL 3.0093 mL
25 mM 0.0963 mL 0.4815 mL 0.9630 mL 2.4074 mL
30 mM 0.0802 mL 0.4012 mL 0.8025 mL 2.0062 mL
40 mM 0.0602 mL 0.3009 mL 0.6019 mL 1.5046 mL
50 mM 0.0481 mL 0.2407 mL 0.4815 mL 1.2037 mL
60 mM 0.0401 mL 0.2006 mL 0.4012 mL 1.0031 mL
80 mM 0.0301 mL 0.1505 mL 0.3009 mL 0.7523 mL
100 mM 0.0241 mL 0.1204 mL 0.2407 mL 0.6019 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ipratropium-d3 bromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ipratropium-d3Sch 1000-d3mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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