2. Others
  3. Others
  4. IP2

IP2 is an immunomodulatory agent. IP2 increases PTP (Pioneer Translation Product)-derived antigen presentation in cancer cells. IP2 shows non-cytotoxic for cancer cells. IP2 induces tumor growth defects in mouse.

For research use only. We do not sell to patients.

IP2 Chemical Structure

IP2 Chemical Structure

CAS No. : 2247640-44-2

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

IP2 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

IP2 is an immunomodulatory agent. IP2 increases PTP (Pioneer Translation Product)-derived antigen presentation in cancer cells. IP2 shows non-cytotoxic for cancer cells. IP2 induces tumor growth defects in mouse[1].

In Vitro

IP2 (35 µM) shows immunomodulatory activity in murine MCA205 fibrosarcoma cells[1].
IP2 (35 µM) increases in the intron-derived SL8 antigen presentation[1].
IP2 (10 µM; 72 h) shows non-cytotoxic for cancer cells[1].
IP2 (10 µM) shows selectivity against three G-protein coupled receptor ADRB1 (35%), HRH2 (40%), and OPRD1 (53%), and inhibits the three enzymes of COX1 (52.8%), PDE3A (84.8%), and PDE4D2 (87.2%)[1].
IP2 (10 µM) dose not induce immunogenic cell death hallmarks in human osteosarcoma U2OS cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IP2 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MCF-7, A549, HCT116, K562, MCA205, B16F10, K562R, HUVEC cells
Concentration: 10 µM
Incubation Time: 72 h
Result: Showed non-cytotoxic for cancer cells.
In Vivo

IP2 (0.711 mg/kg for i.p. for mice; 9.103 mg/kg for i.v. for nice; 26.76 mg/kg for i.v. for dog) shows a high bioavailability in mice[1].
IP2 (50, 100, 250, 500 mg/kg; i.p.) shows very well toleration in C57BL/6 mice[1].
IP2 (2.5 mg/kg; i.v.) induces tumor growth defects in C57BL/6 mice[1].
IP2 (5 mg/kg; intratumor injection; three times per week for 2 weeks) induces tumor growth defects in C57BL/6 mice[1].
Pharmacokinetic Parameters of IP2 in Male C57BL/6J mice and male beagle dog[1].

Dose (mg/kg) Cmax (ng/mL) Tmax (h) T1/2 (h) CL (mL/min/kg) F % MRT0-t (h) AUCtot (ng/mL·h) AUCextra (%)
ip mice 9.103 2078 0.0833 0.8 154 86 0.7 982.3 1.3
iv mice 0.711 322.7 0.0833 1.1 133 0.9 88.8 15.2
iv dog 26.76 272 (µg/mL) 0.0833 3.8 0.69 3.8 654.7 (µg/mL·h) 0.9
Male C57BL/6J mice and male beagle dog; 0.711 mg/kg for i.p. for mice; 9.103 mg/kg for i.v. for mice; 26.76 mg/kg for i.v. for dog[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice and male beagle dog[1]
Dosage: 0.711 mg/kg for i.p. for mice; 9.103 mg/kg for i.v. for nice; 26.76 mg/kg for i.v. for dog
Administration: I.p. or i.v.
Result: Exhibited a high bioavailability in mice and a very low clearance in dogs and a moderate half-life of elimination.
Animal Model: Female C57BL/6 mice[1]
Dosage: 50, 100, 250, 500 mg/kg
Administration: I.p.
Result: Showed very well toleration in C57BL/6 mice.
Animal Model: C57BL/6 mice[1]
Dosage: 5 mg/kg
Administration: Intratumor injection; three times per week for 2 weeks
Result: Shows a 50% decreased in MCA205 WT fibrosarcoma growth at killing.
Clinical Trial
Molecular Weight

814.40

Formula

C32H20Na4O16P2
CAS No.
SMILES

OC1=C2C(C=C(OC2=CC(OP(O[Na])(O[Na])=O)=C1)C3=CC=C(C(C4=C(C5=C(C=C4OP(O[Na])(O[Na])=O)O)OC(C6=CC=C(C=C6)OC)=CC5=O)=C3)OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

IP2 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IP22247640-44-2IP 2IP-2OthersAntitumornon-cytotoxicMCA205 WT cellsC57BL/6J miceG-protein coupled receptorSpliceosomeimmuneInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
IP2
Cat. No.:
HY-144655
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.