Ilmofosine  (Synonyms: BM41440)

Ilmofosine (BM41440) is a potent and selective protein kinase C inhibitor. Ilmofosine induces cell cycle arrest at the G2 phase. Ilmofosine also is an anti-leishmanial agent^[1][2].

Ilmofosine inhibits amastigotes of Leishmania donovani and an antimony-resistant line of L. infantum with ED₅₀ values of 3.73, 3.46 µM^[1].
Ilmofosine (15 µM; 48 h) induces cell cycle arrest at G2 phase in CA46 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

525.77

C₂₆H₅₆NO₅PS

83519-04-4

CCCCCCCCCCCCCCCCSCC(COC)COP(OCC[N+](C)(C)C)([O-])=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Croft SL, et al. Antileishmanial activity of the ether phospholipid ilmofosine. Trans R Soc Trop Med Hyg. 1993 Mar-Apr;87(2):217-9.  [Content Brief]

  [2]. Hofmann J, et al. The protein kinase C inhibitor ilmofosine (BM 41 440) arrests cells in G2 phase and suppresses CDC2 kinase activation through a mechanism different from that of DNA damaging agents. Biochem Biophys Res Commun. 1994 Mar 15;199(2):937-43.  [Content Brief]