2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. Interleukin Related NADPH Oxidase
  4. Hidrosmin

Hidrosmin, a flavonoid, is derived from Diosmin (HY-N0178). hidrosmin exerts a beneficial effect against diabetic nephropathy (DN) by reducing inflammation, oxidative stress, and senescence pathways. Hidrosmin can be used for the research of venous insufficiency and diabetes mellitus.

For research use only. We do not sell to patients.

Hidrosmin Chemical Structure

Hidrosmin Chemical Structure

CAS No. : 115960-14-0

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Hidrosmin Related Antibodies

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Description

Hidrosmin, a flavonoid, is derived from Diosmin (HY-N0178). hidrosmin exerts a beneficial effect against diabetic nephropathy (DN) by reducing inflammation, oxidative stress, and senescence pathways. Hidrosmin can be used for the research of venous insufficiency and diabetes mellitus[1].

IC50 & Target

IL-1β

 

NOX1

 

NOX4

 

In Vitro

Hidrosmin (0.1-1 mM) downregulates the cytokine expression in renal cells exposed to high-glucose and/or inflammatory conditions and also modulates redox balance genes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hidrosmin Related Antibodies

RT-PCR[1]

Cell Line: HK2 cells
Concentration: 0.1, 0.3, 1 mM
Incubation Time: pretreated for 90 min with hidrosmin before stimulation with either high-glucose (30 mM D-Glucose (HY-B0389)) for 24 h, or a combination of human cytokines interleukin-6 (IL-6, 102 U/mL) and interfero
Result: Reduced the gene expression of CC chemokines (CCL2 and CCL5) and proinflammatory cytokines (IL-1β and TNFα) induced by 24 h high-glucose stimulation. Restored the expression of redox balance genes by preventing the prooxidant enzyme NADPH oxidase (NOX1 and NOX4 isoforms) and promoting the expression of antioxidant enzymes Superoxide dismutase-1 (SOD1) and Catalase (CAT) in HK2 cells exposed to high-glucose, as well as to cytokines.
In Vivo

Hidrosmin (300 mg/kg, Orally through the feeding, once daily for 7 weeks) ameliorates renal damage in diabetic mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ApoE KO mice (14-16-week-old, induced T1D by streptozotocin injection)[1]
Dosage: 300 mg/kg/day, dissolved in tap water
Administration: Orally through the feeding, once daily for 7 weeks (hidrosmin solution were renewed every 2-3 days)
Result: Did not modify body weight, glycemia, and other biochemical parameters in diabetic mice, except for total cholesterol and low-density lipoprotein (LDL)-cholesterol, which presented a significant reduction when compared with the control group. Ameliorated renal dysfunction by reducing UACR levels. Showed a significant decrease in the urinary KIM-1 levels.
Molecular Weight

652.60

Formula

C30H36O16
CAS No.
SMILES

OCCOC1=C2C(OC(C3=CC(O)=C(C=C3)OC)=CC2=O)=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)O)O)O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Hidrosmin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hidrosmin115960-14-0Interleukin RelatedNADPH OxidaseILNOXDiabetes mellitusdiabetic nephropathynephroprotectiveOrally activeInhibitorinhibitorinhibit

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