2. Metabolic Enzyme/Protease Apoptosis
  3. E1/E2/E3 Enzyme Apoptosis
  4. HA-9104

HA-9104 is a potent and selective inhibitor of cullin-5 neddylation via virtually targeting the V30 pocket of UBE2F. HA-9104 binds to UBE2F, reduces its protein levels, and consequently inhibits cullin-5 neddylation. HA-9104 has potent growth suppression and radiosensitizing activities via targeting the UBE2F-CRL5 axis and causing DNA damage, leading to induction of apoptosis and G2/M arrest in lung and pancreatic cancer cells.

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HA-9104 Chemical Structure

HA-9104 Chemical Structure

CAS No. : 2412367-83-8

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1 mg USD 160 In-stock
5 mg USD 350 In-stock
10 mg USD 525 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

HA-9104 is a potent and selective inhibitor of cullin-5 neddylation via virtually targeting the V30 pocket of UBE2F. HA-9104 binds to UBE2F, reduces its protein levels, and consequently inhibits cullin-5 neddylation. HA-9104 has potent growth suppression and radiosensitizing activities via targeting the UBE2F-CRL5 axis and causing DNA damage, leading to induction of apoptosis and G2/M arrest in lung and pancreatic cancer cells[1].

Molecular Weight

465.55

Formula

C28H27N5O2
CAS No.
Appearance

Solid

SMILES

O=C(NC1=CC=C(N2CCN(CC2)C(C3=CC=C(C)C=C3)=O)C=C1)/C=C/C4=CNC5=C4C=CC=N5
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (214.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1480 mL 10.7400 mL 21.4800 mL
5 mM 0.4296 mL 2.1480 mL 4.2960 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1480 mL 10.7400 mL 21.4800 mL 53.6999 mL
5 mM 0.4296 mL 2.1480 mL 4.2960 mL 10.7400 mL
10 mM 0.2148 mL 1.0740 mL 2.1480 mL 5.3700 mL
15 mM 0.1432 mL 0.7160 mL 1.4320 mL 3.5800 mL
20 mM 0.1074 mL 0.5370 mL 1.0740 mL 2.6850 mL
25 mM 0.0859 mL 0.4296 mL 0.8592 mL 2.1480 mL
30 mM 0.0716 mL 0.3580 mL 0.7160 mL 1.7900 mL
40 mM 0.0537 mL 0.2685 mL 0.5370 mL 1.3425 mL
50 mM 0.0430 mL 0.2148 mL 0.4296 mL 1.0740 mL
60 mM 0.0358 mL 0.1790 mL 0.3580 mL 0.8950 mL
80 mM 0.0268 mL 0.1342 mL 0.2685 mL 0.6712 mL
100 mM 0.0215 mL 0.1074 mL 0.2148 mL 0.5370 mL
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HA-9104 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HA-91042412367-83-8HA9104HA 9104E1/E2/E3 EnzymeApoptosisE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseDNA damagelung cancerpancreatic cancercullin-5 neddylationUBE2FUBE2F-CRL5Inhibitorinhibitorinhibit

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