2. Gene
  3. Plk3 - polo-like kinase 3 Gene

Plk3 - polo-like kinase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Cnk; Fnk

Gene ID: 58936 | Gene type: protein coding

About Plk3

Primary_assembly 5: 130,607,142-130,612,317 reverse strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 203 orthologues, 4 paralogues and is associated with 3 phenotypes. Biased expression in Lung (RPKM 39.2), Spleen (RPKM 33.7) and 9 other tissues.

Summary

Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including Golgi disassembly; intracellular signal transduction; and positive regulation of protein catabolic process. Located in dendrite and neuronal cell body. Orthologous to human PLK3 (polo like kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Plk3 Products(1)

mRNA Protein Name
NM_022187.1 NP_071523.1 serine/threonine-protein kinase PLK3

Plk3 Protein Structure

STKc_PLK3

STKc_PLK3: cd14189 (59 - 313)

POLO_box_1

POLO_box_1: cd13118 (460 - 548)

POLO_box_2

POLO_box_2: cd13117 (561 - 628)

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  • 647 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PLK3

FGF-inducible kinase

PLK-3

cytokine inducible kinase

cytokine-inducible serine/threonine-protein kinase

serine-threonine kinase

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12137 Volasertib Inhibitor 99.41% Yes
HY-12137A Volasertib trihydrochloride Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-50698 BI 2536 Inhibitor 99.95% Phase 2
HY-147298 Plogosertib Inhibitor 99.95% Phase 2
HY-15160 TAK-960 Inhibitor 99.75% Phase 1
HY-15160B TAK-960 dihydrochloride Inhibitor 99.19% Phase 1
HY-15160A TAK-960 hydrochloride Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10197 Wortmannin Inhibitor 99.86% Unkown
HY-100789 ON1231320 Inhibitor 99.24% Unkown
HY-11003 GW843682X Inhibitor 99.75% Unkown
HY-18009 (Z)-LFM-A13 Inhibitor 99.97% Unkown
HY-108597 TC-S 7005 Inhibitor 99.56% Unkown
HY-12134 Poloxin Inhibitor 98.01% Unkown
HY-15158 SBE13 Hydrochloride Inhibitor 99.66% Unkown
HY-110002 LFM-A13 Inhibitor / Unkown
HY-15158A SBE13 Inhibitor / Unkown
HY-149100 PLK1-IN-6 Inhibitor / Unkown
HY-115589 YLT-11 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plk3 NCBI NCBI:1263