2. Gene
  3. ARHGAP21 - Rho GTPase activating protein 21 Gene

ARHGAP21 - Rho GTPase activating protein 21 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ARHGAP10

Gene ID: 57584 | Gene type: protein coding

About ARHGAP21

Cytogenetic location: 10p12.1 Genomic coordinates (GRCh38): 10:24,583,614-24,723,887 (from NCBI)

This gene has 19 transcripts (splice variants), 274 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 26.0), fat (RPKM 12.0) and 25 other tissues.

Summary

ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]

ARHGAP21 Products(10)

mRNA Protein Name
NM_001367447.1 NP_001354376.1 rho GTPase-activating protein 21 isoform b
NM_001367448.1 NP_001354377.1 rho GTPase-activating protein 21 isoform a
NM_001367449.1 NP_001354378.1 rho GTPase-activating protein 21 isoform c
NM_001367450.1 NP_001354379.1 rho GTPase-activating protein 21 isoform c
NM_001367451.1 NP_001354380.1 rho GTPase-activating protein 21 isoform b
NM_001367452.1 NP_001354381.1 rho GTPase-activating protein 21 isoform d
NM_001367453.1 NP_001354382.1 rho GTPase-activating protein 21 isoform b
NM_001367454.1 NP_001354383.1 rho GTPase-activating protein 21 isoform a
NM_001367455.1 NP_001354384.1 rho GTPase-activating protein 21 isoform e
NM_020824.4 NP_065875.3 rho GTPase-activating protein 21 isoform a

ARHGAP21 Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (93 - 155)

PH

PH: PH domain (933 - 1038)

RhoGAP

RhoGAP: RhoGAP domain (1162 - 1312)

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  • 1958 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 21

Rho-GTPase activating protein 10

Related Diseases

Diseases Alias
Aarskog-Scott Syndrome

Aarskog Syndrome

Faciogenital Dysplasia

Faciodigitogenital Syndrome

AAS

Fgdy

X-Linked Aarskog Syndrome

Intellectual Developmental Disorder, X-Linked, Syndromic 16

Aarskog Syndrome, X-Linked

Intellectual Developmental Disorder, X-Linked Syndromic 16

Greig'S Syndrome

Aarskog Scott Syndrome

Aarskog Disease

Scott Aarskog Syndrome

Facio-Digito-Genital Dysplasia

Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder

Aarskog-Scott Syndrome ) Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00921 ARHGAP21 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ARHGAP21 RGD RGD:1311028
Canis familiaris ARHGAP21 VGNC VGNC:38051
Felis catus ARHGAP21 VGNC VGNC:59879
Bos taurus ARHGAP21 VGNC VGNC:26080
Macaca mulatta ARHGAP21 VGNC VGNC:100296
Mus musculus ARHGAP21 MGD MGI:1918685