2. Gene
  3. PPARD - peroxisome proliferator activated receptor delta Gene

PPARD - peroxisome proliferator activated receptor delta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB

Gene ID: 5467 | Gene type: protein coding

About PPARD

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,342,558-35,428,178 (from NCBI)

This gene has 5 transcripts (splice variants), 421 orthologues and 18 paralogues. Ubiquitous expression in placenta (RPKM 13.1), thyroid (RPKM 10.8) and 25 other tissues.

Summary

This gene encodes a member of the Peroxisome Proliferator-activated Receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal Cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]

PPARD Products(35)

mRNA Protein Name
XM_047418931.1 XP_047274887.1 peroxisome proliferator-activated receptor delta isoform X1
NM_001171818.2 NP_001165289.1 peroxisome proliferator-activated receptor delta isoform 1
XM_006715123.2 XP_006715186.1 peroxisome proliferator-activated receptor delta isoform X1
XM_011514710.2 XP_011513012.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418920.1 XP_047274876.1 peroxisome proliferator-activated receptor delta isoform X1
NM_001171819.2 NP_001165290.1 peroxisome proliferator-activated receptor delta isoform 3
XM_017010973.2 XP_016866462.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418932.1 XP_047274888.1 peroxisome proliferator-activated receptor delta isoform X2
XM_047418933.1 XP_047274889.1 peroxisome proliferator-activated receptor delta isoform X2
XM_047418934.1 XP_047274890.1 peroxisome proliferator-activated receptor delta isoform X2
XM_047418926.1 XP_047274882.1 peroxisome proliferator-activated receptor delta isoform X1
XM_005249193.2 XP_005249250.1 peroxisome proliferator-activated receptor delta isoform X1
NM_006238.5 NP_006229.1 peroxisome proliferator-activated receptor delta isoform 1
XM_024446474.2 XP_024302242.1 peroxisome proliferator-activated receptor delta isoform X2
XM_047418915.1 XP_047274871.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418919.1 XP_047274875.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418935.1 XP_047274891.1 peroxisome proliferator-activated receptor delta isoform X2
XM_047418918.1 XP_047274874.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418936.1 XP_047274892.1 peroxisome proliferator-activated receptor delta isoform X2
XM_047418924.1 XP_047274880.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418923.1 XP_047274879.1 peroxisome proliferator-activated receptor delta isoform X1
XM_017010974.2 XP_016866463.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418922.1 XP_047274878.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418927.1 XP_047274883.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418921.1 XP_047274877.1 peroxisome proliferator-activated receptor delta isoform X1
NM_001171820.2 NP_001165291.1 peroxisome proliferator-activated receptor delta isoform 4
XM_047418917.1 XP_047274873.1 peroxisome proliferator-activated receptor delta isoform X1
NM_177435.3 NP_803184.1 peroxisome proliferator-activated receptor delta isoform 2
XM_047418930.1 XP_047274886.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418928.1 XP_047274884.1 peroxisome proliferator-activated receptor delta isoform X1
XM_011514707.2 XP_011513009.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418925.1 XP_047274881.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418929.1 XP_047274885.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418916.1 XP_047274872.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418937.1 XP_047274893.1 peroxisome proliferator-activated receptor delta isoform X2

PPARD Protein Structure

zf-C4

zf-C4: Zinc finger, C4 type (two domains) (73 - 139)

Hormone_recep

Hormone_recep: Ligand-binding domain of nuclear hormone receptor (239 - 415)

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  • 441 a.a.
Protein Preferred Names Protein Names

peroxisome proliferator-activated receptor delta

PPAR-beta

PPAR-delta

PPARD/MYO1D fusion

nuclear hormone receptor 1

nuclear receptor subfamily 1 group C member 2

peroxisome proliferator-activated receptor beta

Related Diseases

Diseases Alias
Diabetes Mellitus

Diabetes
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Abdominal Obesity-Metabolic Syndrome 1

Metabolic Syndrome X

Metabolic Syndrome

AOMS1

Dysmetabolic Syndrome X

Metabolic Disease

Abdominal Obesity Metabolic Syndrome
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2

Abdominal Obesity-Metabolic Syndrome

Abdominal Obesity Metabolic Syndrome

Metabolic Syndrome X

Aoms2

Aoms1
Skin Disease

Skin Diseases

Abnormality Of The Skin

Skin Diseases, Genetic

Genodermatosis

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
Lipid Metabolism Disorder

Dyslipidemia

Disorder Of Fatty Acid Metabolism

Lipid Metabolism Disorders

Fatty Acid Metabolism Disorder

Disorder Of Lipid Metabolism

Abnormality Of Lipid Metabolism

Lipid Metabolism, Inborn Errors

Dyslipidemias

Disorders Of Lipid Metabolism

Congenital Disorders Of Lipid Metabolism

Inherited Disorders Of Lipid Metabolism
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Cardiovascular System Disease

Abnormality Of The Cardiovascular System

Disease Of Subdivision Of Hemolymphoid System

Disorder Of Cardiovascular System

Cardiovascular Diseases

Cardiovascular Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10922 PPARD Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10923 Ppard Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10924 Ppard Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PPARD VGNC VGNC:68976
Rattus norvegicus PPARD RGD RGD:3370
Bos taurus PPARD VGNC VGNC:33182
Macaca mulatta PPARD VGNC VGNC:76228
Canis familiaris PPARD VGNC VGNC:44835
Mus musculus PPARD MGD MGI:101884