2. Gene
  3. PRKD3 - protein kinase D3 Gene

PRKD3 - protein kinase D3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EPK2; PKD3; PRKCN; PKC-NU; nPKC-NU

Gene ID: 23683 | Gene type: protein coding

About PRKD3

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:37,250,502-37,324,833 (from NCBI)

This gene has 10 transcripts (splice variants), 272 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 16.0), testis (RPKM 14.3) and 25 other tissues.

Summary

This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this Enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate Cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]

PRKD3 Products(9)

mRNA Protein Name
XM_047443852.1 XP_047299808.1 serine/threonine-protein kinase D3 isoform X1
XM_005264238.4 XP_005264295.1 serine/threonine-protein kinase D3 isoform X2
XM_005264237.5 XP_005264294.1 serine/threonine-protein kinase D3 isoform X1
XM_017003744.3 XP_016859233.1 serine/threonine-protein kinase D3 isoform X4
XM_047443856.1 XP_047299812.1 serine/threonine-protein kinase D3 isoform X5
NM_005813.6 NP_005804.1 serine/threonine-protein kinase D3
XM_047443855.1 XP_047299811.1 serine/threonine-protein kinase D3 isoform X4
XM_047443854.1 XP_047299810.1 serine/threonine-protein kinase D3 isoform X3
XM_047443853.1 XP_047299809.1 serine/threonine-protein kinase D3 isoform X1

PRKD3 Protein Structure

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (156 - 205)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (272 - 321)

PH

PH: PH domain (418 - 506)

Pkinase

Pkinase: Protein kinase domain (580 - 832)

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  • 890 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase D3

protein kinase C nu type

protein kinase EPK2

Recombinant PRKD3 Proteins

Cat. No. Product Name Accession Purity
HY-P73699 PRKD3/nPKC nu Protein, Human (sf9, GST) O94806 (S2-P890) ≥95%

Related Diseases

Diseases Alias
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Conventional Lipoma

Classic Type Lipoma
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11148 PRKD3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS11149 Prkd3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS11150 Prkd3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PRKD3 VGNC VGNC:44988
Mus musculus PRKD3 MGD MGI:1922542
Bos taurus PRKD3 VGNC VGNC:33338
Rattus norvegicus PRKD3 RGD RGD:1310236
Macaca mulatta PRKD3 VGNC VGNC:76415
Felis catus PRKD3 VGNC VGNC:69066
Others PRKD3 NCBI