1. Gene
  2. ABCB9 - ATP binding cassette subfamily B member 9 Gene

ABCB9 - ATP binding cassette subfamily B member 9 Gene

Homo sapiens

Also known as TAPL; EST122234

Gene ID: 23457 | Gene type: protein coding

About ABCB9

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,918,610-122,975,114 (from NCBI)

This gene has 20 transcripts (splice variants), 209 orthologues and 10 paralogues. Broad expression in testis (RPKM 3.4), brain (RPKM 1.2) and 23 other tissues.

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of Peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. [provided by RefSeq, Jul 2011]

ABCB9 Products(5)

mRNA Protein Name
NM_001243013.2 NP_001229942.1 ABC-type oligopeptide transporter ABCB9 isoform 6
NM_001243014.2 NP_001229943.1 ABC-type oligopeptide transporter ABCB9 isoform 5
NM_019624.4 NP_062570.1 ABC-type oligopeptide transporter ABCB9 isoform 2
NM_019625.4 NP_062571.1 ABC-type oligopeptide transporter ABCB9 isoform 1
NM_203444.4 NP_982269.2 ABC-type oligopeptide transporter ABCB9 isoform 4

ABCB9 Protein Structure

ABC_membrane

ABC_membrane: ABC transporter transmembrane region (190 - 451)

ABC_tran

ABC_tran: ABC transporter (522 - 671)

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  • 600
  • 766 a.a.
Protein Preferred Names Protein Names

ABC-type oligopeptide transporter ABCB9

ABC transporter 9 protein

Orthologs Information

Species Symbol Source ID
Bos taurus ABCB9 VGNC VGNC:25467
Rattus norvegicus ABCB9 RGD RGD:620254
Felis catus ABCB9 VGNC VGNC:80417
Mus musculus ABCB9 MGD MGI:1861729
Canis familiaris ABCB9 VGNC VGNC:97182
Macaca mulatta ABCB9 VGNC VGNC:81341