MTUS2 - microtubule associated scaffold protein 2 Gene

Homo sapiens

Also known as ICIS; CAZIP; TIP150; KIAA0774

Gene ID: 23281 | Gene type: protein coding

About MTUS2

Cytogenetic location: 13q12.3 Genomic coordinates (GRCh38): 13:28,819,963-29,505,947 (from NCBI)

This gene has 6 transcripts (splice variants), 261 orthologues and 2 paralogues. Biased expression in heart (RPKM 7.4), ovary (RPKM 1.3) and 4 other tissues.

Summary

Enables microtubule binding activity and protein homodimerization activity. Part of nucleus. Colocalizes with centrosome and cytoplasmic microtubule. [provided by Alliance of Genome Resources, Apr 2022]

MTUS2 Products(6)

mRNA	Protein	Name
NM_001033602.4	NP_001028774.3	microtubule-associated tumor suppressor candidate 2 isoform a
NM_001366650.1	NP_001353579.1	microtubule-associated tumor suppressor candidate 2 isoform c
NM_001366651.1	NP_001353580.1	microtubule-associated tumor suppressor candidate 2 isoform d
NM_001384605.1	NP_001371534.1	microtubule-associated tumor suppressor candidate 2 isoform a
NM_001384606.1	NP_001371535.1	microtubule-associated tumor suppressor candidate 2 isoform a
NM_015233.6	NP_056048.1	microtubule-associated tumor suppressor candidate 2 isoform b

Protein Preferred Names

Protein Names

microtubule-associated tumor suppressor candidate 2

+TIP of 150 kDa

Related Diseases

Diseases

Alias

Lung Non-Squamous Non-Small Cell Carcinoma

Non- Squamous Nsclc

Temporal Arteritis

Polymyalgia Rheumatica	Giant Cell Arteritis
Cranial Arteritis	Horton Disease
Gca	Horton'S Disease
Rhizomelic Pseudopolyarthritis	Arteritis Cranialis
Arteritis Temporalis	Horton'S Arteritis
Horton'S Giant Cell Arteritis	Horton'S Temporal Arteritis
Horton'S Syndrome	Gca - [Giant Cell Arteritis]
Senile Arthritis	Polymyalgia Arteritica
Pmr - [Polymyalgia Rheumatica]	Forestier-Certonciny Syndrome
Rheumatic Polymyalgia	Polymyalgia

Orbital Plasma Cell Granuloma

Orbital Myositis	Orbital Pseudotumor
Pseudotumor Of Orbit	Plasma Cell Granuloma, Orbital

Acute Interstitial Pneumonia

Acute Interstitial Pneumonitis	Hamman-Rich Syndrome
Accelerated Interstitial Pneumonia	Aip
Hamman-Rich Disease	Idiopathic Pulmonary Fibrosis, Acute Fatal Form
Idiopathic Pulmonary Fibrosis

Thyroid Crisis

Thyrotoxic Crisis	Thyroid Storm
Thyrotoxic Storm

Pylorus Cancer

Ca Pylorus - Stomach	Malignant Neoplasm Of Prepylorus
Malignant Neoplasm Of Pylorus Of Stomach	Malignant Tumor Of Pylorus
Malignant Neoplasm Of Pylorus

Chronic Orbital Inflammation

Chronic Inflammation Of Orbit

Thymus Squamous Cell Carcinoma

Epidermoid Thymic Carcinoma

Thymic Squamous Cell Carcinoma

Pleomorphic Carcinoma

Acth Deficiency, Isolated

Adrenocorticotropic Hormone Deficiency	IAD
Congenital Isolated Acth Deficiency	Isolated Acth Deficiency
Isolated Adrenocorticotropic Hormone Deficiency	Adrenocorticotropic Hormone Deficiency
Adrenocorticotropic Hormone [Acth] Deficiency	Secondary Adrenocortical Insufficiency

Extrinsic Cardiomyopathy

Acute Thyroiditis

Infectious Thyroiditis

Cryptogenic Organizing Pneumonia

Bronchiolitis Obliterans Organizing Pneumonia	Boop
Constrictive Bronchiolitis	Cryptogenic Organizing Pneumonitis
Cop	Bronchiolitis Obliterans Organising Pneumonia
Cryptogenic Organising Pneumonia	Cryptogenic Organising Pneumonitis
Idiopathic Bronchiolitis Obliterans With Organising Pneumonia	Idiopathic Bronchiolitis Obliterans With Organizing Pneumonia
Organizing Pneumonia	Idiopathic Boop
Idiopathic Bronchiolitis Obliterans Organizing Pneumonia	Organized Pneumonia

Exanthem

Exanthema	Rash
Rashes

Gastroesophageal Junction Adenocarcinoma

Adenocarcinoma Of Cardioesophageal Junction	Adenocarcinoma Of Gastroesophageal Junction
Adenocarcinoma Of The Gastroesophageal Junction

Granulomatous Hepatitis

Pericardium Disease

Gastroesophageal Adenocarcinoma

Gastric And Esophageal Adenocarcinoma

Gastro-Esophageal Adenocarcinoma

Transverse Myelitis

Myelitis Transverse

Myelitis, Transverse

Tolosa-Hunt Syndrome

Painful Ophthalmoplegia	Tolosa Hunt Syndrome
Nonspecific Inflammation Of The Cavernous Sinus Or Superior Orbital Fissure	Ths
Ophthalmoplegia, Painful

Tenosynovitis

Inflammation Of Tendon Sheath

Synovitis Or Tenosynovitis

Central Nervous System Vasculitis

Vasculitis, Central Nervous System

Aseptic Meningitis

Acute Aseptic Meningitis	Meningitis Aseptic
Meningitis, Aseptic

Autoimmune Myocarditis

Severe Cutaneous Adverse Reaction

Stevens-Johnson Syndrome	Toxic Epidermal Necrolysis
Drug-Induced Stevens Johnson Syndrome	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
Susceptibility To Severe Cutaneous Adverse Reaction	Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
Lyell'S Syndrome	Lyell Syndrome
Severe Cutaneous Adverse Reaction, Susceptibility To	Hypersensitivity Syndrome, Carbamazepine-Induced, Susceptibility To
Hypersensitivity Syndrome, Carbamazepine-Induced	Stevens-Johnson Syndrome, Susceptibility To
Toxic Epidermal Necrolysis, Susceptibility To	Sjs/Ten
Susceptibility To Severe Cutaneous Adverse Reaction Ity To	Mycoplasma-Induced Stevens Johnson Syndrome
Dermatostomatitis, Stevens Johnson Type	Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum
Sjs-Ten	Toxic Epidermolysis
SJS	Dermatostomatitis Stevens Johnson Type
Ten	Sjs/Ten - [Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis]
Ten - [Toxic Epidermal Necrolysis]

Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1

Vitiligo	VAMAS1
Slev1	Vtlg
Systemic Lupus Erythematosus, Vitiligo-Related	Vitiligo-Associated Multiple Autoimmune Disease 1
Systemic Lupus Erythematosus Vitiligo-Related

Thyroid Gland Disease

Abnormality Of The Thyroid Gland

Thyroid Diseases

Necrotizing Gastritis

Lung Combined Large Cell Neuroendocrine Carcinoma

Combined Large Cell Neuroendocrine Carcinoma Of Lung	Pulmonary Combined Large Cell Neuroendocrine Carcinoma
Combined Large Cell Lung Neuroendocrine Carcinoma

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Mediastinum Sarcoma

Sarcoma Of Mediastinum

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

Head And Neck Cancer

Head And Neck Neoplasm	Head And Neck Tumours
Head/Neck Neoplasm	Tumor Of Head And Neck
Head And Neck Neoplasms	Hnc
Cancer, Head/Neck

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer	Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Carcinoma	Hereditary Nonpolyposis Colorectal Neoplasms
Familial Nonpolyposis Colon Cancer	Hnpcc
Coca 1	Hereditary Defective Mismatch Repair Syndrome
Hereditary Non-Polyposis Colon Cancer	Hereditary Non-Polyposis Colon Cancer Syndrome
Hereditary Non-Polyposis Colorectal Cancer	Hereditary Non-Polyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colon Cancer Syndrome	Hereditary Nonpolyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colorectal Neoplasm	Hnpcc - Hereditary Nonpolyposis Colon Cancer
Cancer Family Syndrome	Familial Nonpolyposis Colorectal Cancer
Colon Cancer, Familial Nonpolyposis	Colorectal Neoplasms, Hereditary Nonpolyposis
Cancer, Colorectal, Nonpolyposis, Hereditary	Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08827	MTUS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MTUS2	VGNC	VGNC:82358
Rattus norvegicus	MTUS2	RGD	RGD:1562533
Bos taurus	MTUS2	VGNC	VGNC:31757
Macaca mulatta	MTUS2	VGNC	VGNC:106273
Canis familiaris	MTUS2	VGNC	VGNC:43497
Mus musculus	MTUS2	MGD	MGI:1915388