1. Gene
  2. Nlrp3 - NLR family, pyrin domain containing 3 Gene

Nlrp3 - NLR family, pyrin domain containing 3 Gene

Mus musculus

Also known as FCU; MWS; FCAS; Cias1; Mmig1; NALP3; Pypaf1; AII/AVP; AGTAVPRL

Gene ID: 216799 | Gene type: protein coding

About Nlrp3

Chromosome 11: 59,432,394-59,457,782 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 87 orthologues, 22 paralogues and is associated with 95 phenotypes. Broad expression in spleen adult (RPKM 1.1), lung adult (RPKM .8) and 25 other tissues.

Summary

Enables DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of T-helper cell differentiation; positive regulation of cytokine production; and response to bacterium. Acts upstream of or within several processes, including NLRP3 inflammasome complex assembly; activation of cysteine-type endopeptidase activity involved in apoptotic process; and defense response to virus. Located in cytoplasm and nucleus. Part of NLRP3 inflammasome complex. Is expressed in central nervous system and retina. Used to study CINCA Syndrome; familial cold autoinflammatory syndrome 1; and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Nlrp3 Products(2)

mRNA Protein Name
NM_001359638.1 NP_001346567.1 NACHT, LRR and PYD domains-containing protein 3
NM_145827.4 NP_665826.1 NACHT, LRR and PYD domains-containing protein 3

Nlrp3 Protein Structure

Pyrin_NALPs

Pyrin_NALPs: cd08320 (7 - 87)

FISNA

FISNA: pfam14484 (135 - 205)

NACHT

NACHT: pfam05729 (215 - 384)

NOD2_WH

NOD2_WH: pfam17779 (459 - 515)

LRR_RI

LRR_RI: cd00116 (572 - 949)

LRR_RI

LRR_RI: sd00033 (739 - 767)

LRR_RI

LRR_RI: sd00033 (768 - 795)

LRR_RI

LRR_RI: sd00033 (796 - 824)

LRR_RI

LRR_RI: sd00033 (825 - 852)

LRR_RI

LRR_RI: sd00033 (853 - 881)

LRR_RI

LRR_RI: sd00033 (882 - 909)

LRR_RI

LRR_RI: sd00033 (910 - 934)

LRR_RI

LRR_RI: sd00033 (939 - 966)

LRR_RI

LRR_RI: smart00368 (964 - 991)

LRR_RI

LRR_RI: sd00033 (967 - 991)

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  • 1033 a.a.
Protein Preferred Names Protein Names

NACHT, LRR and PYD domains-containing protein 3

NACHT/LRR/pyrin domain-containing protein 3

PYRIN-containing APAF1-like protein 1

cold autoinflammatory syndrome 1 protein homolog

cryopyrin

mast cell maturation-associated-inducible protein 1

Recombinant Nlrp3 Proteins

Cat. No. Product Name Accession Purity
HY-P71598 NLRP3 Protein, Mouse (His-SUMO) Q8R4B8-1 (M1-R153) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Nlrp3 NCBI NCBI:114548