Notch1 - notch 1 Gene

Mus musculus

Also known as N1; Mis6; Tan1; lin-12; 9930111A19Rik

Gene ID: 18128 | Gene type: protein coding

About Notch1

Chromosome 2: 26,347,915-26,406,675 reverse strand.GRCm39:CM000995.3

This gene has 11 transcripts (splice variants), 273 orthologues, 4 paralogues and is associated with 55 phenotypes. Broad expression in thymus adult (RPKM 56.2), lung adult (RPKM 46.1) and 21 other tissues.

Summary

Enables several functions, including Notch binding activity; chromatin DNA binding activity; and transcription coactivator activity. Involved in several processes, including blood vessel endothelial cell differentiation; heart development; and negative regulation of cell differentiation. Acts upstream of or within several processes, including animal organ development; nervous system development; and tube morphogenesis. Located in several cellular components, including adherens junction; apical plasma membrane; and cell surface. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Orthologous to human NOTCH1 (Notch receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Notch1 Products(1)

mRNA	Protein	Name
NM_008714.3	NP_032740.3	neurogenic locus notch homolog protein 1 precursor

Notch1 Protein Structure

EGF_CA

Notch

NOD

NODP

JMTM_Notch1

ANKYR

ANK

ANKYR

Ank_2

ANK

PHA03247

0
400
800
1200
1600
2000
2400
2531 a.a.

Protein Preferred Names

Protein Names

neurogenic locus notch homolog protein 1

Motch A	Notch gene homolog 1
mT14	major type A protein
p300

Recombinant Notch1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71166	NOTCH1 Protein, Mouse (HEK293, His)	Q01705 (A18-Q526)	≥95%
HY-P73324	NOTCH1 Protein, Mouse (sf9, His)	Q01705 (A19-Q526)	≥95%
HY-P79173	NOTCH1 Protein, Mouse (CHO, mFc)	AAM28905 (A19-Q526)	≥95%

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-10585	Valproic acid	98.40%	Unkown
HY-10585A	Valproic acid sodium	98.14%	Unkown
HY-10585B	Valproic acid (sodium)(2:1)	/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0711	Carvacrol		99.96%	Phase 3
HY-15670	BMS-906024	Inhibitor	98.10%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99258	Brontictuzumab	Inhibitor	95.00%	Phase 1

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13027	DAPT		99.91%	Unkown
HY-N0133	Tangeretin		99.27%	Unkown
HY-N0232	Psoralidin		99.90%	Unkown
HY-14174	MRK-560	Inhibitor	≥99.0%	Unkown
HY-134978A	(+)SHIN2	Inhibitor	99.11%	Unkown
HY-12860	BMS-986115	Inhibitor	99.81%	Unkown
HY-12465	Z-Ile-Leu-aldehyde		97.28%	Unkown
HY-10585AS1	Valproic acid-d14 sodium		96.45%	Unkown
HY-10585S1	Valproic acid-d6		98.71%	Unkown
HY-144899	ASR-490	Inhibitor	99.05%	Unkown
HY-P1985A	Notch 1 TFA		95.03%	Unkown
HY-10585AS	Valproic acid-d7 sodium		/	Unkown
HY-10585S	Valproic acid-d4		≥98.0%	Unkown
HY-103539	3,5-Bis(4-nitrophenoxy)benzoic acid	Inhibitor	/	Unkown
HY-10585S2	Valproic acid-d15		≥99.0%	Unkown
HY-10585S3	Valproic acid-d4 sodium		/	Unkown
HY-10585S4	Valproic acid-d4-1		/	Unkown
HY-N9790	Procyanidin B2 3,3'-di-O-gallate	Inhibitor	/	Unkown
HY-RS09445	NOTCH1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09446	Notch1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09447	Notch1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W032013S3	1-Octanol-d5	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Notch1	NCBI	NCBI:4851

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