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  2. Lta - lymphotoxin A Gene

Lta - lymphotoxin A Gene

Mus musculus

Also known as LT; Ltx; Tnfb; LT[a]; LT-[a]; TNFSF1; Tnlg1e; hlb382; LTalpha; Tnfsf1b; LT-alpha; TNF-beta

Gene ID: 16992 | Gene type: protein coding

About Lta

Chromosome 17: 35,422,141-35,424,327 reverse strand.GRCm39:CM001010.3

This gene has 1 transcript (splice variant), 239 orthologues, 8 paralogues and is associated with 96 phenotypes. Biased expression in spleen adult (RPKM 15.), mammary gland adult (RPKM 7.3) and 2 other tissues.

Summary

Predicted to enable tumor necrosis factor receptor binding activity. Acts upstream of or within several processes, including lymph node development; positive regulation of immune response; and positive regulation of interferon-gamma production. Predicted to be located in extracellular space. Is expressed in several structures, including extraembryonic component; gut; hemolymphoid system; liver; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); glucose metabolism disease (multiple); leishmaniasis (multiple); and lung disease (multiple). Orthologous to human LTA (lymphotoxin alpha). [provided by Alliance of Genome Resources, Apr 2022]

Lta Products(1)

mRNA Protein Name
NM_010735.2 NP_034865.1 lymphotoxin-alpha precursor

Lta Protein Structure

TNF

TNF: pfam00229 (73 - 201)

  • 0
  • 100
  • 202 a.a.
Protein Preferred Names Protein Names

lymphotoxin-alpha

TNF beta

tumor necrosis factor ligand 1e

tumor necrosis factor ligand superfamily member 1

Recombinant Lta Proteins

Cat. No. Product Name Accession Purity
HY-P700228AF Animal-Free TNF beta Protein, Mouse (His) P09225 (L34-L202) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Lta NCBI NCBI:4049
Canis familiaris Lta NCBI NCBI:607183
Macaca fascicularis Lta NCBI NCBI:102138497
Rattus norvegicus Lta NCBI NCBI:25008
Macaca mulatta Lta NCBI NCBI:715425