2. Gene
  3. Il12a - interleukin 12a Gene

Il12a - interleukin 12a Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as p35; Ll12a; Il-12a; IL-12p35

Gene ID: 16159 | Gene type: protein coding

About Il12a

Chromosome 3: 68,597,977-68,605,880 forward strand.GRCm39:CM000996.3

This gene has 6 transcripts (splice variants), 234 orthologues and is associated with 14 phenotypes.

Summary

Enables interleukin-12 beta subunit binding activity. Contributes to cytokine activity. Acts upstream of or within several processes, including T-helper 1 cell activation; defense response to protozoan; and positive regulation of T cell activation. Located in cell surface; cytoplasm; and extracellular space. Part of interleukin-12 complex. Is expressed in brain; lung; small intestine; testis; and thymus. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A). [provided by Alliance of Genome Resources, Apr 2022]

Il12a Products(6)

mRNA Protein Name
NM_001159424.3 NP_001152896.2 interleukin-12 subunit alpha isoform 2 precursor
NM_001410419.1 NP_001397348.1 interleukin-12 subunit alpha isoform 5
NM_001410417.1 NP_001397346.1 interleukin-12 subunit alpha isoform 3 precursor
NM_001410418.1 NP_001397347.1 interleukin-12 subunit alpha isoform 4
NM_001410420.1 NP_001397349.1 interleukin-12 subunit alpha isoform 5
NM_008351.4 NP_032377.1 interleukin-12 subunit alpha isoform 2 precursor

Recombinant Il12a Proteins

Cat. No. Product Name Accession Purity
HY-P7208 IL-12 Protein, Mouse (CHO) P43431 (R23-A215) & P43432 (M23-S335) ≥95%
HY-P70666 IL-12 Protein, Mouse (HEK293) P43431 (R23-A215) & P43432 (M23-S335) ≥95%
HY-P73157 IL-12 Protein, Mouse (HEK293, Fc) P43431 (R23-A215) & P43432 (M23-S335) ≥95%
HY-P73158 IL-12 Protein, Mouse (HEK293, His-Fc) P43431 (R23-A215) & P43432 (M23-S335) ≥95%
HY-P73159 IL-12 Protein, Mouse (HEK293, His) P43431 (R23-A215) & P43432 (M23-S335) ≥95%
HY-P700190AF Animal-Free IL-12 alpha Protein, Mouse (His) P43431 (R23-A215) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06677 IL12A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06678 Il12a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06679 Il12a Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il12a NCBI NCBI:3592
Macaca fascicularis Il12a NCBI NCBI:102115316
Macaca mulatta Il12a NCBI NCBI:703205