AANAT - aralkylamine N-acetyltransferase Gene

Homo sapiens

Also known as DSPS; SNAT

Gene ID: 15 | Gene type: protein coding

About AANAT

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,453,351-76,470,117 (from NCBI)

This gene has 4 transcripts (splice variants) and 257 orthologues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate Enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This Enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the Enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

AANAT Products(2)

mRNA	Protein	Name
NM_001088.3	NP_001079.1	serotonin N-acetyltransferase isoform 2
NM_001166579.2	NP_001160051.1	serotonin N-acetyltransferase isoform 1

AANAT Protein Structure

Acetyltransf_1

0
100
207 a.a.

Protein Preferred Names

Protein Names

serotonin N-acetyltransferase

arylalkylamine N-acetyltransferase

Related Diseases

Diseases

Alias

Schopf-Schulz-Passarge Syndrome

SSPS	Eccrine Tumors With Ectodermal Dysplasia
Eccrine Tumors-Ectodermal Dysplasia	Keratosis Palmoplantaris-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome
Palmoplantar Hyperkeratosis-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome	Palmoplantar Keratoderma-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome
Keratosis Palmoplantaris With Cystic Eyelids, Hypodontia, And Hypotrichosis	Keratosis Palmoplantaris With Cystic Eyelids, Hypodontia And Hypotrichosis

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Scoliosis

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-157521	AANAT-IN-1	Inhibitor	/	Unkown
HY-RS00025	AANAT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	AANAT	VGNC	VGNC:59453
Canis familiaris	AANAT	VGNC	VGNC:37413
Macaca mulatta	AANAT	VGNC	VGNC:69468
Mus musculus	AANAT	MGD	MGI:1328365
Rattus norvegicus	AANAT	RGD	RGD:2006
Others	AANAT	NCBI

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