2. Gene
  3. COPE - COPI coat complex subunit epsilon Gene

COPE - COPI coat complex subunit epsilon Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as epsilon-COP

Gene ID: 11316 | Gene type: protein coding

About COPE

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,899,514-18,919,387 (from NCBI)

This gene has 11 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in testis (RPKM 53.6), bone marrow (RPKM 48.5) and 25 other tissues.

Summary

The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

COPE Products(4)

mRNA Protein Name
NM_001330469.2 NP_001317398.1 coatomer subunit epsilon isoform d
NM_007263.4 NP_009194.2 coatomer subunit epsilon isoform a
NM_199442.2 NP_955474.1 coatomer subunit epsilon isoform b
NM_199444.2 NP_955476.1 coatomer subunit epsilon isoform c

COPE Protein Structure

Coatomer_E

Coatomer_E: Coatomer epsilon subunit (16 - 305)

  • 0
  • 100
  • 200
  • 308 a.a.
Protein Preferred Names Protein Names

coatomer subunit epsilon

coatomer epsilon subunit

Related Diseases

Diseases Alias
Neuroschistosomiasis
Cardiomyopathy, Familial Restrictive, 2

RCM2

Restrictive Cardiomyopathy 2

Familial Restrictive Cardiomyopathy 2

Cardiomyopathy, Restrictive, Familial, Type 2
Developmental And Epileptic Encephalopathy 48

DEE48

Epileptic Encephalopathy, Early Infantile, 48

Eiee48

Developmental And Epileptic Encephalopathy, 48

Early Infantile Epileptic Encephalopathy 48
Spastic Paraplegia 39, Autosomal Recessive

SPG39

Ntemnd

Hereditary Spastic Paraplegia 39

Nte-Related Motor Neuron Disorder

Autosomal Recessive Spastic Paraplegia Type 39

Spastic Paraplegia Due To Neuropathy Target Esterase Mutation

Spastic Paraplegia Due To Nte Mutation

Spastic Paraplegia 39

Autosomal Recessive Spastic Paraplegia 39

Nte Related Motor Neuron Disorder

Paraplegia, Spastic, Type 39
Geroderma Osteodysplasticum

Gerodermia Osteodysplastica

Geroderma Osteodysplastica

GO

Walt Disney Dwarfism

Type Of Gerodermia Osteodysplastica
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03024 COPE Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus COPE RGD RGD:1306785
Canis familiaris COPE VGNC VGNC:39506
Felis catus COPE VGNC VGNC:61083
Mus musculus COPE MGD MGI:1891702
Macaca mulatta COPE VGNC VGNC:71314
Bos taurus COPE VGNC VGNC:27595
Others COPE NCBI