RCC1 - regulator of chromosome condensation 1 Gene

Homo sapiens

Also known as CHC1; RCC1-I

Gene ID: 1104 | Gene type: protein coding

About RCC1

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,506,043-28,538,989 (from NCBI)

This gene has 14 transcripts (splice variants), 218 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 13.1), lymph node (RPKM 11.7) and 25 other tissues.

Summary

Enables several functions, including guanyl-nucleotide exchange factor activity; nucleosomal DNA binding activity; and protein heterodimerization activity. Involved in several processes, including G1/S transition of mitotic cell cycle; regulation of mitotic nuclear division; and spindle organization. Located in chromatin; cytoplasm; and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

RCC1 Products(6)

mRNA	Protein	Name
NM_001048194.4	NP_001041659.1	regulator of chromosome condensation isoform a
NM_001048195.4	NP_001041660.1	regulator of chromosome condensation isoform b
NM_001048199.3	NP_001041664.1	regulator of chromosome condensation isoform c
NM_001269.6	NP_001260.1	regulator of chromosome condensation isoform c
NM_001381865.2	NP_001368794.1	regulator of chromosome condensation isoform c
NM_001381866.2	NP_001368795.1	regulator of chromosome condensation isoform c

RCC1 Protein Structure

RCC1

0
100
200
300
421 a.a.

Protein Preferred Names

Protein Names

regulator of chromosome condensation

cell cycle regulatory protein

Related Diseases

Diseases

Alias

Microcystic Meningioma

Raynaud Disease

Raynaud'S Disease	Raynaud Phenomenon
Raynaud'S Syndrome	Raynaud'S
Cold Fingers, Hereditary	Raynaud'S Phenomenon
Raynaud'S Disease/Phenomenon	Raynauds Syndrome
Raynauds Phenomenon	Secondary Raynaud'S Phenomenon
Raynaud Syndrome

Retinitis Pigmentosa 3

RP3	Retinitis Pigmentosa 15
Rp15	Choroidoretinal Degeneration With Retinal Reflex In Heterozygous Women
Cone-Rod Degeneration, X-Linked	Retinitis Pigmentosa Type 15
X-Linked Cone-Rod Degeneration	X-Linked Retinitis Pigmentosa 3
Xlrp3	Xlrp-3
Retinitis Pigmentosa-3	Retinitis Pigmentosa, Type 3

Joubert Syndrome 7

JBTS7	Cerebello-Oculo-Renal Syndrome 3
Cors3	Joubert Syndrome, Type 7

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119425	Razoxane	Inhibitor	99.16%	Unkown
HY-RS11783	RCC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RCC1	RGD	RGD:1592835
Bos taurus	RCC1	VGNC	VGNC:33825
Macaca mulatta	RCC1	VGNC	VGNC:107115
Felis catus	RCC1	VGNC	VGNC:64544
Mus musculus	RCC1	MGD	MGI:1913989
Canis familiaris	RCC1	VGNC	VGNC:45440
Others	RCC1	NCBI

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