2. Gene
  3. CDC42EP3 - CDC42 effector protein 3 Gene

CDC42EP3 - CDC42 effector protein 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UB1; CEP3; BORG2

Gene ID: 10602 | Gene type: protein coding

About CDC42EP3

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:37,641,944-37,672,949 (from NCBI)

This gene has 6 transcripts (splice variants), 207 orthologues and 5 paralogues. Broad expression in prostate (RPKM 28.7), endometrium (RPKM 27.8) and 23 other tissues.

Summary

This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin Cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

CDC42EP3 Products(6)

mRNA Protein Name
NM_001270436.2 NP_001257365.1 cdc42 effector protein 3
NM_001270437.2 NP_001257366.1 cdc42 effector protein 3
NM_001270438.2 NP_001257367.1 cdc42 effector protein 3
NM_001371569.1 NP_001358498.1 cdc42 effector protein 3
NM_001371570.1 NP_001358499.1 cdc42 effector protein 3
NM_006449.5 NP_006440.2 cdc42 effector protein 3

CDC42EP3 Protein Structure

PBD

PBD: P21-Rho-binding domain (30 - 81)

BORG_CEP

BORG_CEP: Cdc42 effector (102 - 253)

  • 0
  • 100
  • 200
  • 254 a.a.
Protein Preferred Names Protein Names

cdc42 effector protein 3

CDC42 effector protein (Rho GTPase binding) 3

Related Diseases

Diseases Alias
Vertebrobasilar Insufficiency

Vertebro-Basilar Insufficiency

Vertebrobasilar Arterial Insufficiency

Vertebrobasilar Artery Syndrome
Retinitis Pigmentosa 11

RP11

Retinitis Pigmentosa-11

Retinitis Pigmentosa, Type 11
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02304 CDC42EP3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CDC42EP3 VGNC VGNC:39002
Rattus norvegicus CDC42EP3 RGD RGD:1305858
Macaca mulatta CDC42EP3 VGNC VGNC:70777
Mus musculus CDC42EP3 MGD MGI:2384718
Bos taurus CDC42EP3 VGNC VGNC:27074
Felis catus CDC42EP3 VGNC VGNC:60661