1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugates
  3. E3 ligase Ligand-Linker Conjugate 11

E3 ligase Ligand-Linker Conjugate 11 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker Conjugate 11 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

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E3 ligase Ligand-Linker Conjugate 11 Chemical Structure

E3 ligase Ligand-Linker Conjugate 11 Chemical Structure

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Description

E3 ligase Ligand-Linker Conjugate 11 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker Conjugate 11 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

IC50 & Target

Cereblon (CRBN)[1]

Molecular Weight

469.58

Formula

C25H35N5O4

SMILES

O=C1NC(CCC1N2C(C3=C(C=C(C=C3)N4CCN(CC4)CC5CCN(CC5)CCO)C2)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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E3 ligase Ligand-Linker Conjugate 11 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
E3 ligase Ligand-Linker Conjugate 11
Cat. No.:
HY-162184
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