(E)-Aztreonam (Synonyms: SQ-28429)

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(E)-Aztreonam (SQ-28429) is a monocyclic beta-lactam antibiotic. (E)-Aztreonam has the potential for the research of infections caused by gram-negative pathogens.

For research use only. We do not sell to patients.

(E)-Aztreonam Chemical Structure

CAS No. : 99341-02-3

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Description

(E)-Aztreonam (SQ-28429) is a monocyclic beta-lactam antibiotic. (E)-Aztreonam has the potential for the research of infections caused by gram-negative pathogens^[1]^[2]^[3].

In Vivo

(E)-Aztreonam (28 mg/kg; i.p.; daily for 14 days) induces an increased level of cellular activation in peritoneal cells, increasing the capacity of IL-1 production by peritoneal macrophages in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-8 weeks, male BALB/c mice^[3]
Dosage:	7, 14, 28, 57 mg/kg
Administration:	I.p.; daily for 7 days, 28 mg/kg daily for 14 days
Result:	Increased every immune parameter treatment with 28 mg/kg per day of aztreonam over 14 days, treatment with 57 mg/kg per day of aztreonam for 7 days only enhanced the natural killer (NK) activity of splenocytes.

Molecular Weight

435.43

Formula

C₁₃H₁₇N₅O₈S₂

CAS No.

99341-02-3

SMILES

CC(C)(O/N=C(C1=CSC(N)=N1)/C(N[C@H]2[C@H](C)N(S(=O)(O)=O)C2=O)=O)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Neu HC. Aztreonam activity, pharmacology, and clinical uses. Am J Med. 1990 Mar 23;88(3C):2S-6S; discussion 38S-42S. [Content Brief]

[2]. Childs, S. J., et al. Aztreonam. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1986, 6(4), 138-149.

[3]. Ortega E, et al. Effects of aztreonam on natural immunity in mice. Int J Antimicrob Agents. 1999 Sep;13(1):41-6. [Content Brief]

(E)-Aztreonam Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-Aztreonam99341-02-3SQ-28429SQ28429SQ 28429AntibioticBacterialmonobactamantibioticIL-1 productionInhibitorinhibitorinhibit

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