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  5. DMBA

DMBA  (Synonyms: 7,12-DMBA; 7,12-Dimethylbenzanthracene)

Cat. No.: HY-W011845 Purity: 99.93%
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DMBA has carcinogenic activity as a polycyclic aromatic hydrocarbon (PAH). DMBA is used to induce tumor formation in various rodent models.

For research use only. We do not sell to patients.

DMBA Chemical Structure

DMBA Chemical Structure

CAS No. : 57-97-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Solid
50 mg USD 50 In-stock
100 mg USD 80 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

DMBA has carcinogenic activity as a polycyclic aromatic hydrocarbon (PAH). DMBA is used to induce tumor formation in various rodent models[1].

In Vivo

DMBA can be used in animal modeling to construct chemically induced skin carcinogenesis, breast cancer and other cancer models.
DMBA (0-150 mg/kg, p.o.) results in a decrease in spleen weight and in the total lymphocytes recovered from the spleen in C57BL/6 mice. DMBA exhibits a terminal deposition half-life of 45 min at all dose ranges (5-50 mg) in SD rats[5]. DMBA (0-150 mg/kg, p.o.) results in a decrease in spleen weight and in the total lymphocytes recovered from the spleen in C57BL/6 mice. DMBA exhibits a terminal deposition half-life of 45 min at all dose ranges (5-50 mg) in SD rats[5].

1. Induction of breast cancer[2]
Background
DMBA activates AhR, which translocates into nucleus and dimerizes with cofactor ARNT, thus induces the expressions of protooncogenes c-myc.
Specific Mmodeling Methods
Rat: Sprague-Dawley?•?female?•?50 days •140-150 g
Administration: 15-20 mg DMBA ?•?intragastric gavage?•?single dose
Note
1.5-2 g DMBA dissolved in 100 ml sesame oil
Modeling Indicators
Palpation:Detection of mammary cancer in 150 days.
Histology analysis:The tumor exhibits tightly spaced chords epithelial cells, cysts and papillary structures.
Phenotype:develops a temporary cessation in body growth.
Correlated Product(s)
Opposite Product(s) Phytic acid (HY-N0814); Limonene (HY-N0544)