D-Ala-Lys-AMCA TFA 

D-Ala-Lys-AMCA TFA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA TFA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA TFA can be used for characterizing PEPT1-specific substrates or inhibitors^[1][2].

D-Ala-Lys-AMCA (25, 50 and 150 μM, 3 h) TFA may be transported into liver cancer and Caco-2 cells^[1].
D-Ala-Lys-AMCA (25 μM, 10 min) TFA can be uptaken by absorptive enterocytes of all small intestine segments, whereas there is a complete lack of fluorescence in colonic samples^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

546.49

C₂₃H₂₉F₃N₄O₈

480

390

OC(C(F)(F)F)=O.NC1=CC=C(C(C)=C(CC(NCCCC[C@H](NC([C@@H](C)N)=O)C(O)=O)=O)C(O2)=O)C2=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Gong Y, et al. Specific expression of proton-coupled oligopeptide transporter 1 in primary hepatocarcinoma-anovel strategy for tumor-targeted therapy. Oncol Lett. 2017 Oct;14(4):4158-4166.  [Content Brief]

  [2]. Groneberg DA, et al. Intestinal peptide transport: ex vivo uptake studies and localization of peptide carrier PEPT1. Am J Physiol Gastrointest Liver Physiol. 2001 Sep;281(3):G697-704.  [Content Brief]