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CRT0063465 is a Ligand of HumanPGK1andStress Sensor DJ1, with theKdof 24 μM ofPGK1. CRT0063465 modulates the shelterin complex composition and telomere Length.

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CRT0063465 Chemical Structure

CRT0063465 Chemical Structure

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Based on 1 publication(s) in Google Scholar

CRT0063465 Related Antibodies

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Description

CRT0063465 is a Ligand of HumanPGK1andStress Sensor DJ1, with theKdof 24 μM ofPGK1. CRT0063465 modulates the shelterin complex composition and telomere Length[1].

In Vivo

CRT0063465 (10, 100 nM, up to 84 days) blocks hypoglycemic telomere shortening in TCT116 cells[1].
CRT0063465 (10 nM, 1 week) modulates the composition of shelterin complexes in unstressed HCT116 cells[1].
CRT0063465 (100 nM, up to 100 h) has protective effect against Bleomycin (HY-17565)-induced cytotoxicity in A2780 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

374.23

Formula

C17H16BrN3O2
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=C(CCC(O)=O)C(C)=NC2=CC(C3=CC=C(Br)C=C3)=NN12
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (53.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6722 mL 13.3608 mL 26.7215 mL
5 mM 0.5344 mL 2.6722 mL 5.3443 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6722 mL 13.3608 mL 26.7215 mL 66.8038 mL
5 mM 0.5344 mL 2.6722 mL 5.3443 mL 13.3608 mL
10 mM 0.2672 mL 1.3361 mL 2.6722 mL 6.6804 mL
15 mM 0.1781 mL 0.8907 mL 1.7814 mL 4.4536 mL
20 mM 0.1336 mL 0.6680 mL 1.3361 mL 3.3402 mL
25 mM 0.1069 mL 0.5344 mL 1.0689 mL 2.6722 mL
30 mM 0.0891 mL 0.4454 mL 0.8907 mL 2.2268 mL
40 mM 0.0668 mL 0.3340 mL 0.6680 mL 1.6701 mL
50 mM 0.0534 mL 0.2672 mL 0.5344 mL 1.3361 mL
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CRT0063465 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRT0063465CRT 0063465CRT-0063465OthersTelomereCell agingTCT116A2780Glycolytic kinaseOxidative stress sensorInhibitorinhibitorinhibit

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