Conantokin R  (Synonyms: Con-R)

Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC₅₀ of 93 nM. Conantokin R binds Zn²⁺ and Mg²⁺ with K_ds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity^[1][2].

IC50: 93 nM (NMDA receptor)^[1]

3098.35

C₁₂₇H₂₀₁N₃₅O₄₉S₃

202925-60-8

Gly-Glu-{Gla}-{Gla}-Val-Ala-Lys-Met-Ala-Ala-{Gla}-Leu-Ala-Arg-{Gla}-Asn-Ile-Ala-Lys-Gly-Cys-Lys-Val-Asn-Cys-Tyr-Pro (Disulfide bridge:Cys21-Cys25)

GE-{Gla}-{Gla}-VAKMAA-{Gla}-LAR-{Gla}-NIAKGCKVNCYP (Disulfide bridge:Cys21-Cys25)

OC(C=C1)=CC=C1C[C@H](NC([C@H]2NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC2)NC(CNC([C@H](CCCCN)NC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@H](CC(N)=O)NC([C@H](CC(C(O)=O)C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](C)NC([C@H](C)NC([C@H](CCSC)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](C(C)C)NC([C@H](CC(C(O)=O)C(O)=O)NC([C@H](CC(C(O)=O)C(O)=O)NC([C@H](CCC(O)=O)NC(CN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(C(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCCCN)=O)C(C)C)=O)CC(N)=O)=O)=O)C(N3[C@@H](CCC3)C(O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Blandl T, et al. Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R. FEBS Lett. 2000 Mar 24;470(2):139-46.  [Content Brief]

  [2]. White HS, et al. In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. J Pharmacol Exp Ther. 2000 Jan;292(1):425-32.  [Content Brief]