1. Stem Cell/Wnt TGF-beta/Smad
  2. TGF-beta/Smad
  3. Chlorfortunone A

Chlorfortunone A is a novel sesquiterpenoid dimers, can be isolated from the roots of Chloranthus fortunei. Chlorfortunone A inhibits transforming growth factor (TGF)-β activity.

For research use only. We do not sell to patients.

Chlorfortunone A Chemical Structure

Chlorfortunone A Chemical Structure

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Description

Chlorfortunone A is a novel sesquiterpenoid dimers, can be isolated from the roots of Chloranthus fortunei. Chlorfortunone A inhibits transforming growth factor (TGF)-β activity[1].

In Vitro

Chlorfortunone A (compound 1) (10-40 μM; 4 h) downregulates TGF-β-induced Smad2 phosphorylation (A) and the expression of vimentin (B) in MDA-MB-231 cells[1].
Chlorfortunone A (25 μM; 48 h) significantly downregulated the expression of vimentin, a Smad-regulated EMT-marker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 10, 20, 40 μM
Incubation Time: 4 hours; accompanied with 10 ng/mL TGF-β1 for 30 min
Result: Significantly downregulated the TGF-β-induced p-Smad2 expression in a concentration-dependent manner without any impact on the expression of Smad2/3 protein.

Immunofluorescence[1]

Cell Line: MDA-MB-231 cells
Concentration: 25 μM
Incubation Time: 48 hours
Result: Significantly downregulated the expression of vimentin.
Molecular Weight

490.63

Formula

C31H38O5

SMILES

C[C@@]1([C@@H]2C[C@@H]2C(CC3)=C1[C@]([C@]3(C=C4)C=C[C@@]4([C@@H](C(C)C)C5)[C@@H](C5=O)C)([H])/C6=C(C)/C(OC)=O)[C@@H](O)C6=O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Chlorfortunone A
Cat. No.:
HY-N10577
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