Cefaclor monohydrate 

Cefaclor is a well-absorbed orally active cephalosporin antibiotic. Cefaclor can specifically bind to specific for penicillin-binding protein 3 (PBP3). Cefaclor can be used for the research of depression and kinds of infections caused by bacteria, such as respiratory tract infections, bacterial bronchitis, pharyngitis and skin infections^[1][2][3][4].

Cefaclor (0-500 μg/mL, 12-24 h) shows obvious antibacterial activity against 556 Gram-positive and Gram-negative isolates. The MIC values of most strains are lower than 3.1 μg/mL, and the MIC value of Staph. aureus is 1 μg/mL in vitro^[4].
Cefaclor (60/500 μM, 30 min) is mainly transported by hPepT2 and hPepT1 in the MDCK stably transduced cell line overexpressing hOAT1、hPepT1 and hPepT2^[2].
Cefaclor (0.16 mg/mL, 30 min) can induce allergic reactions by directly activating basophils and mast cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cefaclor (200 mg/kg/day, p.o. once a day for 5 days) can cause intestinal flora imbalance in mice, as well as anxiety and depression-like behaviors in mice. These symptoms can be alleviated by Fluoxetine (HY-B0102) or vagotomy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

385.82

C₁₅H₁₆ClN₃O₅S

70356-03-5

Solid

Off-white to light yellow

O=C(C(N12)=C(Cl)CS[C@]2([H])[C@H](NC([C@H](N)C3=CC=CC=C3)=O)C1=O)O.[H]O[H]

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. 引用1 ：Joo MK, et al. Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice. Sci Rep. 2023 Sep 19;13(1):15529.  [Content Brief]

  [2]. Li M, et al. Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55.  [Content Brief]

  [3]. Yoo HS, et al. Immunologic evaluation of immediate hypersensitivity to cefaclor. Yonsei Med J. 2014 Nov;55(6):1473-83.  [Content Brief]

  [4]. Neu HC, et al. Cefaclor: in vitro spectrum of activity and beta-lactamase stability. Antimicrob Agents Chemother. 1978 Apr;13(4):584-8.  [Content Brief]