2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. BRL-37344

BRL-37344 (Fosigotifator (THAM sodium)) is a specific β3-adrenergic receptor agonist. BRL-37344 treatment significantly lowers the body weight of obese mice.

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BRL-37344 Chemical Structure

BRL-37344 Chemical Structure

CAS No. : 90730-96-4

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5 mg USD 300 In-stock
10 mg USD 480 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

BRL-37344 (Fosigotifator (THAM sodium)) is a specific β3-adrenergic receptor agonist. BRL-37344 treatment significantly lowers the body weight of obese mice[1].

IC50 & Target

β3-adrenergic receptor[1]
Molecular Weight

363.84

Formula

C19H22ClNO4
CAS No.
Appearance

Solid

SMILES

O=C(O)COC1=CC=C(C[C@@H](NC[C@H](C2=CC=CC(Cl)=C2)O)C)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (54.97 mM; ultrasonic and adjust pH to 3 with 1 M HCL; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7485 mL 13.7423 mL 27.4846 mL
5 mM 0.5497 mL 2.7485 mL 5.4969 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7485 mL 13.7423 mL 27.4846 mL 68.7115 mL
5 mM 0.5497 mL 2.7485 mL 5.4969 mL 13.7423 mL
10 mM 0.2748 mL 1.3742 mL 2.7485 mL 6.8712 mL
15 mM 0.1832 mL 0.9162 mL 1.8323 mL 4.5808 mL
20 mM 0.1374 mL 0.6871 mL 1.3742 mL 3.4356 mL
25 mM 0.1099 mL 0.5497 mL 1.0994 mL 2.7485 mL
30 mM 0.0916 mL 0.4581 mL 0.9162 mL 2.2904 mL
40 mM 0.0687 mL 0.3436 mL 0.6871 mL 1.7178 mL
50 mM 0.0550 mL 0.2748 mL 0.5497 mL 1.3742 mL
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BRL-37344 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRL-3734490730-96-4BRL37344BRL 37344Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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