2. Protein Tyrosine Kinase/RTK
  3. Src
  4. BMS-243117

BMS-243117 is a potent, and selective benzothiazole based p56Lck inhibitor with an IC50 of 4 nM. BMS-243117 inhibits anti-CD3/anti-CD28 induced PBL proliferation with an IC50 of 1.1 μM. BMS-243117 binds in an extended conformation to the ATP-binding site of Lck.

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BMS-243117 Chemical Structure

BMS-243117 Chemical Structure

CAS No. : 225521-80-2

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BMS-243117 Related Antibodies

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Description

BMS-243117 is a potent, and selective benzothiazole based p56Lck inhibitor with an IC50 of 4 nM. BMS-243117 inhibits anti-CD3/anti-CD28 induced PBL proliferation with an IC50 of 1.1 μM. BMS-243117 binds in an extended conformation to the ATP-binding site of Lck[1].

IC50 & Target[1]

Lck

4 nM (IC50)

Fyn

32 nM (IC50)

Blk

84 nM (IC50)

Src

158 nM (IC50)

Hck

960 nM (IC50)

Lyn

330 nM (IC50)

Fgr

60 nM (IC50)

Molecular Weight

416.92

Formula

C20H21ClN4O2S
CAS No.
SMILES

O=C(C1=CC=C2N=C(NC(NC(C)(C)C)=O)SC2=C1)NC3=C(C)C=CC=C3Cl
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BMS-243117 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-243117225521-80-2BMS243117BMS 243117SrcBenzothiazoleanti-CD3anti-CD28PBL proliferationATP-binding siteInhibitorinhibitorinhibit

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