BIM 23042 

BIM 23042, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca²⁺ release^[1][2][3].

BIM 23042 (5 μM) competitively inhibits Neuromedin B-induced [³H]arachidonate release in huNMBR cells with a K_i of 49 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BIM 23042 (10 μg; IV; a single bolus) attenuates neurogenic swelling and thermal and mechanical sensitization^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1192.45

C₆₃H₇₃N₁₁O₉S₂

111857-96-6

{DNal}-Cys-Tyr-{DTrp}-Lys-Val-Cys-{Nal}-NH2 (Disulfide bridge:Cys2-Cys7)

{DNal}-CY-{DTrp}-KVC-{Nal}-NH2 (Disulfide bridge:Cys2-Cys7)

O=C([C@@H](NC([C@H](CSSC[C@H](NC([C@@H](NC([C@@H](NC1=O)CCCCN)=O)C(C)C)=O)C(N[C@H](C(N)=O)CC2=CC3=C(C=CC=C3)C=C2)=O)NC([C@H](N)CC4=CC5=C(C=CC=C5)C=C4)=O)=O)CC6=CC=C(C=C6)O)N[C@@H]1CC7=CNC8=CC=CC=C78

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. R R Ryan, et al. Pharmacological profiles of two bombesin analogues in cells transfected with human neuromedin B receptors. Eur J Pharmacol. 1996 Jun 13;306(1-3):307-14.  [Content Brief]

  [2]. Santosh K Mishra, et al. A nociceptive signaling role for neuromedin B. J Neurosci. 2012 Jun 20;32(25):8686-95.  [Content Brief]

  [3]. M Orbuch, et al. Discovery of a novel class of neuromedin B receptor antagonists, substituted somatostatin analogues. Mol Pharmacol. 1993 Oct;44(4):841-50.  [Content Brief]