Big Endothelin-1 (22-38), human

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Big Endothelin-1 (22-38), human is derived from human, is the 22-38 fragment of Big Endothelin-1 (ET-1) (1-38). Big ET-1 (1-38) is a propeptide of ET-1, which has potent and long-lasting vasoconstrictor effects, equips a specific enzymatic cleavage of the 38 amino acid chain to form ET-1 (1-21) and the C-terminal fragment Big ET-1 (22-38).

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Big Endothelin-1 (22-38), human Chemical Structure

CAS No. : 124932-61-2

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Description	Big Endothelin-1 (22-38), human is derived from human, is the 22-38 fragment of Big Endothelin-1 (ET-1) (1-38). Big ET-1 (1-38) is a propeptide of ET-1, which has potent and long-lasting vasoconstrictor effects, equips a specific enzymatic cleavage of the 38 amino acid chain to form ET-1 (1-21) and the C-terminal fragment Big ET-1 (22-38)^[1].
In Vitro	Big Endothelin-1 (22-38), human (0.1 μM; 30 min) induces the release of prostacyclin (PGI2) from rabbit, guinea pig, and rat lungs^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Big Endothelin-1 (22-38), human Related Antibodies
In Vivo	Big Endothelin-1 (22-38), human (3 nM/kg; intra-arterial injection; single dose) produces a significant rise in left ventricular systolic pressure (LVSP) in anesthetized rabbits, and is enhanced by cyclooxygenase inhibitor Indomethacin (HY-14397) (5 mg/kg i.v.) significantly^[3]. Big Endothelin-1 (22-38), human (3 nM/kg; intravascular method; single dose), has no antiaggregatory properties for platelet induced by ADP in rabbits^[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	1808.99
Formula	C₈₀H₁₂₅N₂₃O₂₅
CAS No.	124932-61-2
Sequence Shortening	VNTPEHVVPYGLGSPRS
SMILES	[VNTPEHVVPYGLGSPRS]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (260 KB) Handling Instructions (2659 KB)
References	[1]. Hemsén A, et al. Metabolism of Big endothelin-1 (1-38) and (22-38) in the human circulation in relation to production of endothelin-1 (1-21). Regul Pept. 1995 Feb 14;55(3):287-97. [Content Brief] [2]. D'Orléans-Juste P, et al. Human big endothelin releases prostacyclin in vivo and in vitro through a phosphoramidon-sensitive conversion to endothelin-1. J Cardiovasc Pharmacol. 1991;17 Suppl 7:S251-5. [Content Brief] [3]. Huneidi AH, et al. Endothelin-1 and big endothelin cause subarachnoid hemorrhage in the anesthetized rabbit. J Cardiovasc Pharmacol. 1991;17 Suppl 7:S492-5. [Content Brief]