ATX-II 

ATX-II is a specific Na⁺ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II causes delayed inactivation of the Na⁺Ryanodine (HY-103306). ATX-II also induces pulmonary vein arrhythmogenesis and atrial fibrillation^[1][2].

4934.62

C₂₁₃H₃₂₃N₆₃O₆₁S₆

60748-45-0

Gly-Val-Pro-Cys-Leu-Cys-Asp-Ser-Asp-Gly-Pro-Ser-Val-Arg-Gly-Asn-Thr-Leu-Ser-Gly-Ile-Ile-Trp-Leu-Ala-Gly-Cys-Pro-Ser-Gly-Trp-His-Asn-Cys-Lys-Lys-His-Gly-Pro-Thr-Ile-Gly-Trp-Cys-Cys-Lys-Gln (Disulfide bonds: Cys4-Cys44, Cys6-Cys34, Cys27-Cys45)

GVPCLCDSDGPSVRGNTLSGIIWLAGCPSGWHNCKKHGPTIGWCCKQ (Disulfide bonds: Cys4-Cys44, Cys6-Cys34, Cys27-Cys45)

O=C(CN)N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N3[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H]4CC(N)=O)=O)CC5=CNC=N5)=O)CC6=CNC7=CC=CC=C67)=O)=O)CO)=O)CCC3)=O)CSSC[C@H](NC8=O)C(N[C@H](C(N[C@H](C(O)=O)CCC(N)=O)=O)CCCCN)=O)=O)=O)C)=O)CC(C)C)=O)CC9=CNC%10=CC=CC=C9%10)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)=O)CO)=O)CC(C)C)=O)[C@@H](C)O)=O)CC(N)=O)=O)=O)CCCNC(N)=N)=O)C(C)C)=O)CO)=O)CCC2)=O)=O)CC(O)=O)=O)CO)=O)CC(O)=O)=O)CSSC[C@H](NC4=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N%11[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H]%12CC%13=CNC%14=CC=CC=C%13%14)=O)=O)[C@H](CC)C)=O)[C@@H](C)O)=O)CCC%11)=O)=O)CC%15=CNC=N%15)=O)CCCCN)=O)CCCCN)=O)=O)CC(C)C)=O)CSSC[C@@H]8NC%12=O)=O)CCC1)=O)C(C)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Fletcher JE, et al. ATX II, a sodium channel toxin, sensitizes skeletal muscle to halothane, caffeine, and ryanodine. Anesthesiology. 1999 May;90(5):1294-301.  [Content Brief]

  [2]. Lu YY, et al. ATX-II-induced pulmonary vein arrhythmogenesis related to atrial fibrillation and long QT syndrome. Eur J Clin Invest. 2012 Aug;42(8):823-31.  [Content Brief]