ARN11391

Cat. No.: HY-163171: FAQs
Data Sheet Handling Instructions

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ARN 11391 is a selective enhancer of inositol triphosphate receptor type 1 (ITPR1). ARN 11391 can be used in the study of spinocerebellar ataxia.

For research use only. We do not sell to patients.

ARN11391 Chemical Structure

CAS No. : 1214569-31-9

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Biological Activity
Purity & Documentation
References
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Description

ARN 11391 is a selective enhancer of inositol triphosphate receptor type 1 (ITPR1). ARN 11391 can be used in the study of spinocerebellar ataxia^[1].

Molecular Weight

383.48

Formula

C₂₂H₂₉N₃O₃

CAS No.

1214569-31-9

SMILES

O=C(C1=C2C(CCCC2)=NN1CC)NC3=C(OCC4OCCCC4)C=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 38.35 mg/mL (100.01 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6077 mL	13.0385 mL	26.0770 mL
5 mM	0.5215 mL	2.6077 mL	5.2154 mL
10 mM	0.2608 mL	1.3038 mL	2.6077 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Genovese M, et al. Pharmacological potentiators of the calcium signaling cascade identified by high-throughput screening. PNAS Nexus. 2022 Dec 9;2(1):pgac288. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6077 mL	13.0385 mL	26.0770 mL	65.1924 mL
	5 mM	0.5215 mL	2.6077 mL	5.2154 mL	13.0385 mL
	10 mM	0.2608 mL	1.3038 mL	2.6077 mL	6.5192 mL
	15 mM	0.1738 mL	0.8692 mL	1.7385 mL	4.3462 mL
	20 mM	0.1304 mL	0.6519 mL	1.3038 mL	3.2596 mL
	25 mM	0.1043 mL	0.5215 mL	1.0431 mL	2.6077 mL
	30 mM	0.0869 mL	0.4346 mL	0.8692 mL	2.1731 mL
	40 mM	0.0652 mL	0.3260 mL	0.6519 mL	1.6298 mL
	50 mM	0.0522 mL	0.2608 mL	0.5215 mL	1.3038 mL
	60 mM	0.0435 mL	0.2173 mL	0.4346 mL	1.0865 mL
	80 mM	0.0326 mL	0.1630 mL	0.3260 mL	0.8149 mL
	100 mM	0.0261 mL	0.1304 mL	0.2608 mL	0.6519 mL

ARN11391 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARN113911214569-31-9ARN 11391ARN-11391Chloride ChannelCl− ChannelsCalcium signalingInositol triphosphate receptorSpinocerebellar ataxiaInhibitorinhibitorinhibit

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