XBP1 Antibody (YA1424)

XBP1 Antibody (YA1424) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1424), targeting XBP1, with a predicted molecular weight of 29 kDa (observed band size: 29 kDa). XBP1 Antibody (YA1424) can be used for WB, IP experiment in human, mouse background.

The related gene encodes a transcription factor that regulates MHC class II related genes by binding to a promoter element referred to as an X box. The related gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of The related gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target related genes during the recovery phase of ER stress. A pseudorelated gene of XBP1 has been identified and localized to chromosome 5.

7494

Predicted band size: 29 kDa; Observed band size: 29 kDa

Affinity Purified

Non-conjugated

Unmodified

Epigenetics and Nuclear Signaling

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal, Recombinant

Rabbit

Human, Mouse

P17861

WB: 1/500-1/1000;IP: 1/20

WB, IP

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Recombinant protein of human XBP1 aa101-115.