Tissue Factor Antibody (YA2471)

Tissue Factor Antibody (YA2471) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2471), targeting Tissue Factor, with a predicted molecular weight of 33 kDa (observed band size: 45 kDa). Tissue Factor Antibody (YA2471) can be used for WB, IHC-P experiment in human, mouse, rat background.

The related gene encodes coagulation factor III which is a cell surface glycoprotein. The factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, The factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of The factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express The coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. The protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.

2152

Predicted band size: 33 kDa; Observed band size: 45 kDa

Affinity Purified

Non-conjugated

Unmodified

Cardiovascular

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human, Mouse, Rat

P13726

WB: 1/500-1/1000;IHC: 1/50-1/100

WB, IHC-P

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic peptide of human Tissue Factor