SDHB Antibody (YA1580)

SDHB Antibody (YA1580) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1580), targeting SDHB, with a predicted molecular weight of 32 kDa (observed band size: ). SDHB Antibody (YA1580) can be used for WB, IHC-P, IP, FC experiment in human, mouse, rat background.

The tumor suppressor related gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed of four nuclear-encoded subunits. The enzyme complex converts succinate to fumarate which releases electrons as part of the citric acid cycle, and the enzyme complex additionally provides an attachment site for released electrons to be transferred to the oxidative phosphorylation pathway. The SDH enzyme complex plays a role in oxygen-related gene regulation through its conversion of succinate, which is an oxygen sensor that stabilizes the hypoxia-inducible factor 1 (HIF1) transcription factor. Sporadic and familial mutations in The related gene result in paragangliomas, pheochromocytoma, and gastrointestinal stromal tumors, supporting a link between mitochondrial dysfunction and tumorirelated genesis. Mutations in The related gene are also implicated in nuclear type 4 mitochondrial complex II deficiency.

6390

Predicted band size: 32 kDa

Affinity Chromatography

Non-conjugated

Unmodified

Signal Transduction

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human, Mouse, Rat

P21912

WB: 1/500-1/1000;IHC: 1/50-1/100;IP: 1/50;FC: 1/50-1/100

WB, IHC-P, IP, FC

Liquid

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human SDHB