Phospho-Amyloid Precursor Protein (Thr743) Antibody (YA2568)

Phospho-Amyloid Precursor Protein (Thr743) Antibody (YA2568) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2568), targeting Phospho-Amyloid Precursor Protein (Thr743), with a predicted molecular weight of 87 kDa (observed band size: 100 kDa). Phospho-Amyloid Precursor Protein (Thr743) Antibody (YA2568) can be used for WB, ICC/IF, IP experiment in human, rat background.

The related gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in The related gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for The related gene.

351

Predicted band size: 87 kDa; Observed band size: 100 kDa

Affinity Purified

Non-conjugated

Phosphorylated

Neuroscience

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human, Rat

P05067

WB: 1/500-1/1000;IF: 1/50-1/200;IP: 1/20

WB, ICC/IF, IP

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic phosphopeptide corresponding to residues surrounding Thr743 of human Amyloid Precursor Protein