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  4. PEN2 Antibody (YA2118)

PEN2 Antibody (YA2118)

Cat. No.: HY-P82373
User Guide for Antibodies

PEN2 Antibody (YA2118) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2118), targeting PEN2, with a predicted molecular weight of 12 kDa (observed band size: 12 kDa). PEN2 Antibody (YA2118) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

Size Price Stock
10 μL $70 Ask For Quote & Lead Time
50 μL $185 Ask For Quote & Lead Time
100 μL $300 Ask For Quote & Lead Time

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

PEN2 Antibody (YA2118) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2118), targeting PEN2, with a predicted molecular weight of 12 kDa (observed band size: 12 kDa). PEN2 Antibody (YA2118) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

Background

Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein related generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. The related gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for The related gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants.

Gene ID

55851

Synonyms
PEN 2; PSEN2; psenen
Molecular Weight

Predicted band size: 12 kDa; Observed band size: 12 kDa

Purity

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Research Field

Neuroscience

Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Clonality

Recombinant, Monoclonal

Host

Rabbit

Reactivity

Human, Mouse, Rat

SwissProt ID

Q9NZ42

Dilution Ratio

WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200;FC: 1/50-1/100

Application

WB, IHC-P, ICC/IF, FC

Appearance

Liquid

Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Isotype

IgG

Sensitivity

Endogenous

Immunogen

A synthesized peptide derived from human PEN2

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PEN2 Antibody (YA2118)
Cat. No.:
HY-P82373
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