NCF4 Antibody (YA3139)

NCF4 Antibody (YA3139) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3139), targeting NCF4, with a predicted molecular weight of 39 kDa (observed band size: 39 kDa). NCF4 Antibody (YA3139) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human background.

The protein encoded by The related gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. The protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. The complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of The protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of The protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

4689

Predicted band size: 39 kDa; Observed band size: 39 kDa

Affinity Purified

Non-conjugated

Unmodified

-

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

Q15080

WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200;IP: 1/20

WB, IHC-F, IHC-P, ICC/IF, IP

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic peptide of human p40-phox