Kaiso Antibody (YA2543)

Kaiso Antibody (YA2543) is a biotin-conjugated non-conjugated IgG antibody, targeting Kaiso, with a predicted molecular weight of 74 kDa (observed band size: 85 kDa). Kaiso Antibody (YA2543) can be used for WB experiment in human, mouse, rat background.

The related gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target related gene promoters. It may contribute to the repression of target related genes of the Wnt signaling pathway, and may also activate transcription of a subset of target related genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of The protein. Alternatively spliced transcript variants encoding the same protein have been identified.

10009

Predicted band size: 74 kDa; Observed band size: 85 kDa

Affinity Purified

Non-conjugated

Unmodified

Epigenetics and Nuclear Signaling

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human, Mouse, Rat

Q86T24

WB: 1/500-1/1000

WB

Liquid

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human KAISO