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  4. Glutathione Peroxidase 4 Antibody

Glutathione Peroxidase 4 Antibody

Cat. No.: HY-P80692
COA User Guide for Antibodies

Glutathione Peroxidase 4 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 22 kDa, targeting to Glutathione Peroxidase 4. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL $77 In-stock
50 μL $200 In-stock
100 μL $325 In-stock
250 μL   Get quote  

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Top Publications Citing Use of Products
  • Biological Activity

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Description

Glutathione Peroxidase 4 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 22 kDa, targeting to Glutathione Peroxidase 4. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

Background

Glutathione Peroxidase 4: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization. [provided by RefSeq, Dec 2018]

Tag

Free

Gene ID

2879

Synonyms
Phospholipid hydroperoxide glutathione peroxidase; mitochondrial; PHGPx; EC 1.11.1.12; Glutathione peroxidase 4; GPx-4; GSHPx-4
Molecular Weight

Predicted band size: 22 kDa

Purity

affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Research Field

Signal Transduction

Product Categories

Primary Antibody; Rabbit Polyclonal Antibody

Clonality

Polyclonal

Host

Rabbit

Reactivity

Human, Mouse, Rat

SwissProt ID

P36969

Dilution Ratio

WB: 1:500-1:1,000 ;IHC: 1:50-1:100 ;IF: 1:50-1:200

Application

WB, IHC-F, IHC-P, ICC/IF

Appearance

Liquid

Formulation

Supplied in phosphate buffered saline (pH 7.4), 150 mM NaCl and 50% glycerol. Preservative: 0.02% sodium azide

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Isotype

IgG

Sensitivity

Endogenous

Immunogen

Synthetic peptide corresponding to Human GPX4.The exact sequence is proprietary to MCE.

Documentation

Glutathione Peroxidase 4 Antibody Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Glutathione Peroxidase 4 Antibody
Cat. No.:
HY-P80692
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