DLAT Antibody (YA912)

DLAT Antibody (YA912) is an unconjugated, approximately 69 kDa, mouse-derived, anti-DLAT (YA912) monoclonal antibody. DLAT Antibody (YA912) can be used for: WB, ICC/IF, IP expriments in human, mouse background without labeling.

The related gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of The related gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where The protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in The related gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.

1737

Predicted band size: 69 kDa

Affinity Purified

Non-conjugated

Unmodified

Signal Transduction

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse

P10515

WB: 1/500-1/1000; IF: 1/50-1/200; IP: 1/20

WB, ICC/IF, IP

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Endogenous

Purified recombinant human Pyruvate Dehydrogenase E2 protein fragments expressed in E.coli.