1. Natural Products
  2. Others
  3. Adenosine N1-oxide

Adenosine N1-oxide is an oral active anti-inflammatory agent, and can be isolated from royal jelly. Adenosine N1-oxide promotes osteogenic and adipocyte differentiation.

For research use only. We do not sell to patients.

Adenosine N1-oxide Chemical Structure

Adenosine N1-oxide Chemical Structure

CAS No. : 146-92-9

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Adenosine N1-oxide is an oral active anti-inflammatory agent, and can be isolated from royal jelly. Adenosine N1-oxide promotes osteogenic and adipocyte differentiation[1][2].

In Vitro

Adenosine N1-oxide )(1-40 μM, 24 h) inhibits TNF-α and IL-6 secretion by RAW264.7 cells stimulated with 2 µg/mL LPS (HY-D1056)[2].
Adenosine N1-oxide )(20/100 μM, 30 mins) increases intracellular cAMP production in both peritoneal macrophages and RAW264.7 cells in a dose-dependent manner[2].
Adenosine N1-oxide )(5-10 μM, 30 mins) increases the protein level of phosphorylation of Akt and GSK-3β in 2 µg/mL LPS (HY-D1056)-stimulated RAW264.7 cells[2].
Adenosine N1-oxide )(2-10 μM, 6-7 days) promotes osteogenic and adipocyte differentiation in MC3T3-E1 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: RAW264.7 cells
Concentration: 2, 5 and 10 μM
Incubation Time: 30 mins
Result: Increased the protein level of phosphorylation of Akt and GSK-3β in 2 µg/mL LPS (HY-D1056)-stimulated RAW264.7 cells.

Cell Differentiation Assay[2]

Cell Line: MC3T3-E1 cells
Concentration: 2, 5 and 10 μM
Incubation Time: 6-7 days
Result: Promoted osteogenic and adipocyte differentiation in MC3T3-E1 cells
In Vivo

Adenosine N1-oxide (oral administration, 135 mg/kg for three times) reduces the lethality caused by LPS (HY-D1056)-induced endotoxin shock in BALB/c mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced endotoxin shock in BALB/c mice[1]
Dosage: 135 mg/kg for three times
Administration: Oral administration
Result: Reduced the lethality caused by LPS (HY-D1056)-induced endotoxin shock in BALB/c mice.
Molecular Weight

283.24

Formula

C10H13N5O5

CAS No.
SMILES

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N(C=N2)C3=C2C(N)=[N+]([O-])C=N3)O1

Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Adenosine N1-oxide Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Adenosine N1-oxide
Cat. No.:
HY-102082
Quantity:
MCE Japan Authorized Agent: