2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. A-77636 hydrochloride

A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor.

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A-77636 hydrochloride Chemical Structure

A-77636 hydrochloride Chemical Structure

CAS No. : 145307-34-2

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Based on 1 publication(s) in Google Scholar

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A-77636 hydrochloride Related Antibodies

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1 Publications Citing Use of MCE A-77636 hydrochloride

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  • Biological Activity

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Description

A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor[1][2].

In Vivo

A-77636 (0.1-1 mg/kg) exerts a suppressant effect on food intake, due principally to a reduction in meal size and duration[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male hooded rat[1]
Dosage: 0.1, 0.3 and 1.0 mg/kg
Administration: S.c.
Result: Exerted a suppressant effect on food intake, due principally to a reduction in meal size and duration.
Molecular Weight

365.89

Formula

C20H28ClNO3
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

[H]Cl.NC[C@@H]1O[C@@H](CC2=C(O)C(O)=CC=C12)C34C[C@H](C5)C[C@H](C[C@H]5C4)C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 33 mg/mL (90.19 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7331 mL 13.6653 mL 27.3306 mL
5 mM 0.5466 mL 2.7331 mL 5.4661 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (253 KB) Elemental Analysis Report (111 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7331 mL 13.6653 mL 27.3306 mL 68.3265 mL
5 mM 0.5466 mL 2.7331 mL 5.4661 mL 13.6653 mL
10 mM 0.2733 mL 1.3665 mL 2.7331 mL 6.8327 mL
15 mM 0.1822 mL 0.9110 mL 1.8220 mL 4.5551 mL
20 mM 0.1367 mL 0.6833 mL 1.3665 mL 3.4163 mL
25 mM 0.1093 mL 0.5466 mL 1.0932 mL 2.7331 mL
30 mM 0.0911 mL 0.4555 mL 0.9110 mL 2.2776 mL
40 mM 0.0683 mL 0.3416 mL 0.6833 mL 1.7082 mL
50 mM 0.0547 mL 0.2733 mL 0.5466 mL 1.3665 mL
60 mM 0.0456 mL 0.2278 mL 0.4555 mL 1.1388 mL
80 mM 0.0342 mL 0.1708 mL 0.3416 mL 0.8541 mL
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A-77636 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A-77636145307-34-2A77636A 77636Dopamine ReceptorantiparkinsonianfoodintakemeallongactingoralInhibitorinhibitorinhibit

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