2. Membrane Transporter/Ion Channel
  3. Monoamine Transporter
  4. Tetrabenazine-d6

Tetrabenazine-d6  (Synonyms: Ro 1-9569-d6)

Cat. No.: HY-B0590S Purity: 98.75%
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Tetrabenazine-d6 (Deutetrabenazine) is a deuterium-labled Tetrabenazine (HY-B0590), is the first deuterium approved worldwide for the research of Huntington's disease, or other hyperkinetic movement disorders.

For research use only. We do not sell to patients.

Tetrabenazine-d<sub>6</sub> Chemical Structure

Tetrabenazine-d6 Chemical Structure

CAS No. : 1392826-25-3

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10 mg USD 150 In-stock
25 mg USD 250 In-stock
50 mg USD 450 In-stock
100 mg USD 750 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Tetrabenazine-d6:

Tetrabenazine-d6 Related Antibodies

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Description

Tetrabenazine-d6 (Deutetrabenazine) is a deuterium-labled Tetrabenazine (HY-B0590), is the first deuterium approved worldwide for the research of Huntington's disease, or other hyperkinetic movement disorders[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
Potential advantages of deuterated compounds:
(1) Extend the half-life in vivo. Deuterated compounds may be able to prolong the pharmacokinetic characteristics of the compound, that is, prolong the half-life in vivo. This can improve compound safety, efficacy and tolerability, and increase ease of administration.
(2) Improve oral bioavailability. Deuterated compounds may reduce the degree of unwanted metabolism (first-pass metabolism) in the gut wall and liver, allowing a greater proportion of the unmetabolized drug to reach its target site of action. High bioavailability determines its activity at low doses and better tolerance.
(3) Improve metabolic characteristics. Deuterated compounds may reduce the formation of toxic or reactive metabolites and improve drug metabolism.
(4) Improve drug safety. Deuterated compounds may reduce or eliminate adverse side effects of pharmaceutical compounds and are safe.
(5) Preserve the therapeutic properties. Deuterated compounds are expected to retain similar biochemical potency and selectivity to hydrogen analogs in previous studies.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tetrabenazine-d6 Related Antibodies
Clinical Trial
Molecular Weight

323.46

Formula

C19H21D6NO3
CAS No.
Unlabeled CAS

58-46-8
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1[C@H](CC(C)C)CN2CCC3=CC(OC([2H])([2H])[2H])=C(OC([2H])([2H])[2H])C=C3[C@@]2([H])C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (103.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 33.33 mg/mL (103.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.1 mg/mL (0.31 mM; Need ultrasonic)

H2O : 0.1 mg/mL (0.31 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0916 mL 15.4579 mL 30.9157 mL
5 mM 0.6183 mL 3.0916 mL 6.1831 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (250 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 3.0916 mL 15.4579 mL 30.9157 mL 77.2893 mL
5 mM 0.6183 mL 3.0916 mL 6.1831 mL 15.4579 mL
10 mM 0.3092 mL 1.5458 mL 3.0916 mL 7.7289 mL
15 mM 0.2061 mL 1.0305 mL 2.0610 mL 5.1526 mL
20 mM 0.1546 mL 0.7729 mL 1.5458 mL 3.8645 mL
25 mM 0.1237 mL 0.6183 mL 1.2366 mL 3.0916 mL
30 mM 0.1031 mL 0.5153 mL 1.0305 mL 2.5763 mL
40 mM 0.0773 mL 0.3864 mL 0.7729 mL 1.9322 mL
50 mM 0.0618 mL 0.3092 mL 0.6183 mL 1.5458 mL
60 mM 0.0515 mL 0.2576 mL 0.5153 mL 1.2882 mL
80 mM 0.0386 mL 0.1932 mL 0.3864 mL 0.9661 mL
100 mM 0.0309 mL 0.1546 mL 0.3092 mL 0.7729 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Tetrabenazine-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrabenazine-d61392826-25-3Ro 1-9569-d6Monoamine TransporterInhibitorinhibitorinhibit

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