1. Metabolic Enzyme/Protease
  2. Glucosidase
  3. 3-Oxo-hop-22(29)-ene

3-Oxo-hop-22(29)-ene is a yeast α-glucosidase inhibitor. 3-Oxo-hop-22(29)-ene shows a moderate effect on the viability of T. cruzi and L. mexicana. 3-Oxo-hop-22(29)-ene shows marginal activity of anti-inflammatory.

For research use only. We do not sell to patients.

3-Oxo-hop-22(29)-ene Chemical Structure

3-Oxo-hop-22(29)-ene Chemical Structure

CAS No. : 25615-11-6

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Description

3-Oxo-hop-22(29)-ene is a yeast α-glucosidase inhibitor. 3-Oxo-hop-22(29)-ene shows a moderate effect on the viability of T. cruzi and L. mexicana. 3-Oxo-hop-22(29)-ene shows marginal activity of anti-inflammatory[1].

In Vitro

3-Oxo-hop-22(29)-ene (compound 2) (50 μM; 24 hours) reduces the viability of T. cruzi by more than 20%, and has a moderate effecton on T. rangeli and L. mexicana[1].
3-Oxo-hop-22(29)-ene (10, 100 μM; 48 hours) causes 1.51% and 7.39% inhibition activity to yeast α-glucosidase respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Saccharomyces cerevisiae (type 1) and mammalian yeast (type 2) α-glucosidases, T. cruzi, T. rangeli, L. mexicana
Concentration: 10 μM, 50 μM, 100 μM
Incubation Time: 24 hours, 48 hours
Result: Reduced the viability of T. cruzi by more than 20%, and had a moderate effecton on T. rangeli and L. mexicana
Inhibited Yeast α-glucosidase.
In Vivo

3-Oxo-hop-22(29)-ene (0.31 μmol/ear; application; once) decreases 17.50 % the inflammation of mouse ear edema model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male CD-1 mice (25-30 g) (Mouse ear edema model induced by 12-O-tetradecanoylphorbol acetate (TPA))[1]
Dosage: 0.31 μmol/ear
Administration: Apply to both faces of the right ear; once
Result: Decreased 17.50% the inflammation of mouse ear edema model.
Molecular Weight

424.70

Formula

C30H48O

CAS No.
SMILES

C[C@]12[C@@](CC[C@@]3([H])[C@]2(CC[C@]4([H])[C@@]3(CC[C@@H]4C(C)=C)C)C)([H])[C@@]5([C@@](C(C)(C(CC5)=O)C)([H])CC1)C

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
3-Oxo-hop-22(29)-ene
Cat. No.:
HY-N10440
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