2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 2-Methylcitric acid-d3

2-Methylcitric acid-d3  (Synonyms: Methylcitric acid-d3)

Cat. No.: HY-113371S Purity: 98.99%
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2-Methylcitric acid-d3 is the deuterium labeled 2-Methylcitric acid. 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].

For research use only. We do not sell to patients.

2-Methylcitric acid-d<sub>3</sub> Chemical Structure

2-Methylcitric acid-d3 Chemical Structure

CAS No. : 146764-58-1

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1 mg USD 148 In-stock
5 mg USD 445 In-stock
10 mg USD 713 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of 2-Methylcitric acid-d3:

2-Methylcitric acid-d3 Related Antibodies

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Description

2-Methylcitric acid-d3 is the deuterium labeled 2-Methylcitric acid. 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Methylcitric acid-d3 Related Antibodies
Molecular Weight

209.17

Formula

C7H7D3O7
CAS No.
Unlabeled CAS

6061-96-7
Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([2H])C(C(O)=O)C(C(O)=O)(O)CC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (478.08 mM; Need ultrasonic)

DMSO : 100 mg/mL (478.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 100 mg/mL (478.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (478.08 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7808 mL 23.9040 mL 47.8080 mL
5 mM 0.9562 mL 4.7808 mL 9.5616 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO / DMSO / H2O 1 mM 4.7808 mL 23.9040 mL 47.8080 mL 119.5200 mL
5 mM 0.9562 mL 4.7808 mL 9.5616 mL 23.9040 mL
10 mM 0.4781 mL 2.3904 mL 4.7808 mL 11.9520 mL
15 mM 0.3187 mL 1.5936 mL 3.1872 mL 7.9680 mL
20 mM 0.2390 mL 1.1952 mL 2.3904 mL 5.9760 mL
25 mM 0.1912 mL 0.9562 mL 1.9123 mL 4.7808 mL
30 mM 0.1594 mL 0.7968 mL 1.5936 mL 3.9840 mL
40 mM 0.1195 mL 0.5976 mL 1.1952 mL 2.9880 mL
50 mM 0.0956 mL 0.4781 mL 0.9562 mL 2.3904 mL
60 mM 0.0797 mL 0.3984 mL 0.7968 mL 1.9920 mL
80 mM 0.0598 mL 0.2988 mL 0.5976 mL 1.4940 mL
100 mM 0.0478 mL 0.2390 mL 0.4781 mL 1.1952 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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2-Methylcitric acid-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Methylcitric acid-d3146764-58-1Methylcitric acid-d3Endogenous MetaboliteInhibitorinhibitorinhibit

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