18β-Glycyrrhetinic acid-d₃

Name: 18β-Glycyrrhetinic acid-d 3
Brand: MedChemExpress
SKU: HY-N0180S
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0180S Purity: 95.62%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

18β-Glycyrrhetinic acid-d₃ is deuterium labeled 18β-Glycyrrhetinic acid. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

For research use only. We do not sell to patients.

18β-Glycyrrhetinic acid-d<sub>3</sub> Chemical Structure

18β-Glycyrrhetinic acid-d₃ Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 18β-Glycyrrhetinic acid-d₃:

18β-Glycyrrhetinic acid In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

473.70

Formula

C₃₀H₄₃D₃O₄

Unlabeled CAS

471-53-4

Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@@](C(C=C3[C@]2(CC[C@@]4([C@@]3([H])C[C@](C)(CC4)C(O)=O)C)C)=O)([H])[C@@]5([C@@](C(C)([C@@](C([2H])([2H])C5)([2H])O)C)([H])CC1)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (263.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1110 mL	10.5552 mL	21.1104 mL
5 mM	0.4222 mL	2.1110 mL	4.2221 mL
10 mM	0.2111 mL	1.0555 mL	2.1110 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.62%

Select Batch:

Data Sheet (279 KB) SDS (252 KB)

COA (258 KB) HNMR (3504 KB) RP-HPLC (2981 KB) MS (3920 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Huang RY, et al. 18β-Glycyrrhetinic acid suppresses cell proliferation through inhibiting thromboxane synthase in non-small cell lung cancer. PLoS One. 2014 Apr 2;9(4):e93690. [Content Brief]

[3]. Zhou J, et al. 18β-glycyrrhetinic acid suppresses experimental autoimmune encephalomyelitis through inhibition of microglia activation and promotion of remyelination. Sci Rep. 2015 Sep 2;5:13713. [Content Brief]

[4]. Yang G, et al. Protective Effect of 18β-Glycyrrhetinic Acid against Triptolide-Induced Hepatotoxicity in Rats. Evid Based Complement Alternat Med. 2017;2017:3470320. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	2.1110 mL	10.5552 mL	21.1104 mL	52.7760 mL
	5 mM	0.4222 mL	2.1110 mL	4.2221 mL	10.5552 mL
	10 mM	0.2111 mL	1.0555 mL	2.1110 mL	5.2776 mL
	15 mM	0.1407 mL	0.7037 mL	1.4074 mL	3.5184 mL
	20 mM	0.1056 mL	0.5278 mL	1.0555 mL	2.6388 mL
	25 mM	0.0844 mL	0.4222 mL	0.8444 mL	2.1110 mL
	30 mM	0.0704 mL	0.3518 mL	0.7037 mL	1.7592 mL
	40 mM	0.0528 mL	0.2639 mL	0.5278 mL	1.3194 mL
	50 mM	0.0422 mL	0.2111 mL	0.4222 mL	1.0555 mL
	60 mM	0.0352 mL	0.1759 mL	0.3518 mL	0.8796 mL
	80 mM	0.0264 mL	0.1319 mL	0.2639 mL	0.6597 mL
	100 mM	0.0211 mL	0.1056 mL	0.2111 mL	0.5278 mL