2. Stem Cell/Wnt JAK/STAT Signaling Vitamin D Related/Nuclear Receptor GPCR/G Protein Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Prostaglandin Receptor STAT PPAR Endogenous Metabolite
  4. 15-keto-Prostaglandin E2

15-keto-Prostaglandin E2  (Synonyms: 15-keto-PGE2)

Cat. No.: HY-113205 Purity: ≥99.0%
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15-keto-Prostaglandin E2 is an endogenous metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to its Cys259 residue. 15-keto-Prostaglandin E2 can bind and stabilize EP2 and EP4 receptor. 15-keto-Prostaglandin E2 inhibits breast cancer cell growth and progression. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth.

For research use only. We do not sell to patients.

15-keto-Prostaglandin E2 Chemical Structure

15-keto-Prostaglandin E2 Chemical Structure

CAS No. : 26441-05-4

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500 μg USD 151 In-stock

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Based on 1 publication(s) in Google Scholar

Other Forms of 15-keto-Prostaglandin E2:

15-keto-Prostaglandin E2 Related Antibodies

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Description

15-keto-Prostaglandin E2 is an endogenous metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to its Cys259 residue. 15-keto-Prostaglandin E2 can bind and stabilize EP2 and EP4 receptor. 15-keto-Prostaglandin E2 inhibits breast cancer cell growth and progression. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth[1][2][3].

Molecular Weight

350.45

Formula

C20H30O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCC(/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)C/C=C\CCCC(O)=O)=O
Structure Classification
Initial Source

Gracilaria verrucosa (Huds.) Papenf.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (285.35 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8535 mL 14.2674 mL 28.5347 mL
5 mM 0.5707 mL 2.8535 mL 5.7069 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8535 mL 14.2674 mL 28.5347 mL 71.3369 mL
5 mM 0.5707 mL 2.8535 mL 5.7069 mL 14.2674 mL
10 mM 0.2853 mL 1.4267 mL 2.8535 mL 7.1337 mL
15 mM 0.1902 mL 0.9512 mL 1.9023 mL 4.7558 mL
20 mM 0.1427 mL 0.7134 mL 1.4267 mL 3.5668 mL
25 mM 0.1141 mL 0.5707 mL 1.1414 mL 2.8535 mL
30 mM 0.0951 mL 0.4756 mL 0.9512 mL 2.3779 mL
40 mM 0.0713 mL 0.3567 mL 0.7134 mL 1.7834 mL
50 mM 0.0571 mL 0.2853 mL 0.5707 mL 1.4267 mL
60 mM 0.0476 mL 0.2378 mL 0.4756 mL 1.1889 mL
80 mM 0.0357 mL 0.1783 mL 0.3567 mL 0.8917 mL
100 mM 0.0285 mL 0.1427 mL 0.2853 mL 0.7134 mL
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15-keto-Prostaglandin E2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

15-keto-Prostaglandin E226441-05-415-keto-PGE2Prostaglandin ReceptorSTATPPAREndogenous MetabolitePeroxisome proliferator-activated receptorsbreast cancerSTAT3 activationcancerfungal growthInhibitorinhibitorinhibit

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